Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Assessing oral acute toxicity and histopathological effects of Strelitzia reginae Aiton leaf extracts in Zebrafish (Danio rerio Hamilton) Subject The topic of the resource Danio rerio; GC-MS; Histopathology; Mineral content; Strelitzia reginae; Toxicity Description An account of the resource Strelitzia reginae, commonly known as the Bird of Paradise, is a decorative shrub endemic to southern Africa. This study marks the first comprehensive investigation into the safety of S. reginae leaf extract through oral acute toxicity assessments and histopathological examinations in Zebrafish (Danio rerio). The interest in this research arises from the historical use of S. reginae components by various indigenous South African societies to treat conditions like swollen glands and sexual problems. GC-MS analysis was used along with traditional methods to look at the phytochemical parts of S. reginae. The results showed the presence of several substances, such as eicosane, hexacosane, 1-octadecene, and neophytadiene. Notably, the analysis also identified certain chemicals with potential cytotoxic properties, such as octacosane and bis (2-ethylhexyl) phthalate. Drawing upon the biological similarities between Zebrafish and humans, who share a majority of their genes, this study represents the first attempt to evaluate the toxicity and histopathology of S. reginae using D. rerio as the test model, aligning with the OECD recommendations outlined in Article 203. The oral acute toxicity tests were done using ethanolic leaf powdered extracts of S. reginae. Higher concentrations (1200 mg/L) were toxic, but lower doses were less harmful to D. rerio. As observed in the histopathology examination, exposure to higher concentrations of S. reginae extract induced severe histological abnormalities in the Zebrafish's gills, liver, kidneys, intestines, and brain. This work contributes greatly to our understanding of S. reginae's safety profile and its potential therapeutic applications for enhancing well-being. 2024 Horizon e-Publishing Group. All rights reserved. Creator An entity primarily responsible for making the resource Omnes D.S.; Xavier J.; Suresh A. Source A related resource from which the described resource is derived Plant Science Today, Vol-11, No. 2, pp. 262-270. Publisher An entity responsible for making the resource available Horizon e-Publishing Group Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.14719/pst.3092" target="_blank" rel="noreferrer noopener">https://doi.org/10.14719/pst.3092</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191755313&amp;doi=10.14719%2Fpst.3092&amp;partnerID=40&amp;md5=421f4a9a645828ac275c8e6a82d93519" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191755313&amp;doi=10.14719%2fpst.3092&amp;partnerID=40&amp;md5=421f4a9a645828ac275c8e6a82d93519</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 23481900 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Omnes D.S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, University, Karnataka, 560029, India; Xavier J., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, University, Karnataka, 560029, India; Suresh A., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, University, Karnataka, 560029, India