Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Phytochemicals of Nardostachys jatamansi as potential inhibitors of HCV E2 receptor: An in silico study Subject The topic of the resource E2 receptor; Hepatitis C virus; Molecular docking; Nardostachys jatamansi; Toxicity Description An account of the resource Hepatitis C virus (HCV) is the causative agent of acute and chronic hepatitis and can lead to liver cirrhosis. High variability in the HCV genome renders vaccine formulation strenuous. Modern pharmaceuticals rely heavily on plant-based compounds for drug production. This study focuses on in-silico screening of phytochemicals derived from an herbal plant, Nardostachys jatamansi, for the treatment of HCV by inhibiting its E2 receptor, which binds to the hepatocytes, enabling viral entry into the liver. Computer-aided drug design utilizes various tools such as molecular docking tools, including AutoDock Vina, Avogadro, PyMol, Discovery Studio Visualizer, LigPlot+, and online tools like SwissADME (Absorption, Delivery, Metabolism and Excretion) for analysis of pharmacokinetics and pharmacodynamics of phytochemicals. Toxicity studies were carried out using pkCSM. 25 bioactive phytochemicals of N. jatamansi were analysed. The analysis was validated by comparing the data of the phytochemicals with an established antiviral drug, ribavirin. This is a novel approach to docking studies, exploring the possibility of medicinal plants as anti-hepatic drugs. Of the 25 compounds, nardosatachysin and ?-gurjunene are the standout performers and are considered potent inhibitors of HCV E2 receptor. The two compounds are recommended for further in vivo and in vitro trials to assess their efficacy in treating HCV infection. 2024 Lalrintluanga Hnamte, et al. Creator An entity primarily responsible for making the resource Hnamte L.; Nagella P.; Nizam A.; Lakshmaiah V.V. Source A related resource from which the described resource is derived Journal of Applied Biology and Biotechnology, Vol-12, No. 2, pp. 273-281. Publisher An entity responsible for making the resource available Open Science Publishers LLP Inc. Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.7324/JABB.2024.161594" target="_blank" rel="noreferrer noopener">https://doi.org/10.7324/JABB.2024.161594</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185943165&amp;doi=10.7324%2FJABB.2024.161594&amp;partnerID=40&amp;md5=d2321416ab6ddff5b609669aa5bd64e6" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185943165&amp;doi=10.7324%2fJABB.2024.161594&amp;partnerID=40&amp;md5=d2321416ab6ddff5b609669aa5bd64e6</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 2347212X |LS; 2023-2024; Vol-2; 0419-0427 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Hnamte L., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Nagella P., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Nizam A., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Lakshmaiah V.V., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India