Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In-Vitro Investigation of the ?-Amylase Inhibition Activity of Bare Bis-Benzylidene-Cyclohexanone Synthesized by a Highly Selective Solvent-Free Route Subject The topic of the resource Enzyme Inhibition; Molecular Dynamic Simulation; MWCNT; Sulfonic acid; TPD Description An account of the resource Current work reports the highly selective, solvent-free synthesis of an endorsed bioactive compound, Bis benzylidine cyclohexanone (BBC) through solid acid catalysed cross aldol condensation route and checks its in-vitro bio activity. The catalytic support (Multiwalled carbon nanotube) employed was synthesized through the highly sophisticated catalytic chemical vapor deposition (CVD) method and simple mechanical grinding strategy was adopted to decorate sulfonic acid on the support. The C1s X-ray photoelectron peak of at 290.3 eV confirms the effective interaction of sulfonic acid with MWCNT. The sharp and intense desorption peaks observed at approximately 528.7 C and 655.15 C in the TPD analysis unmistakably substantiate the strong acidity of the synthesized system. The alpha amylase inhibition activity of the synthesized compound was calculated to be around 88.5 %, which is in par with the commercial drug as it could inhibit only 96 %. Further, the in-silico (Docking and Molecular Dynamic Simulation) investigations unveiled a new target site for the compound and this can further be studied in detail to advance the applications in drug design. Detailed scrutiny of various parameters was conducted to validate the bioactivity and pharmaceutical potential of the synthesized compound. 2023 Wiley-VCH GmbH. Creator An entity primarily responsible for making the resource Veigas L.M.; Ravi L.; Narasimhaiaha N.; Chundattu S.J.; Nagaraju K.; Krishna Mohan M. Source A related resource from which the described resource is derived ChemistrySelect, Vol-8, No. 47 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/slct.202301807" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/slct.202301807</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179749961&amp;doi=10.1002%2Fslct.202301807&amp;partnerID=40&amp;md5=de298401fd5f01c553aa8d0b62860ee5" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179749961&amp;doi=10.1002%2fslct.202301807&amp;partnerID=40&amp;md5=de298401fd5f01c553aa8d0b62860ee5</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 23656549 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veigas L.M., Department of Sciences and Humanities, Christ (Deemed to be University), School of Engineering and Technology, Mysore Road, Karnataka, Bengaluru, 560074, India; Ravi L., Department of Food Technology, Faculty of Life and Allied Health Sciences, MS Ramaiah University of Applied Sciences, Karnataka, Bengaluru, 560054, India; Narasimhaiaha N., St. Joseph's University, Lalbagh Road, Karnataka, Bengaluru, 560027, India; Chundattu S.J., Department of Sciences and Humanities, Christ (Deemed to be University), School of Engineering and Technology, Mysore Road, Karnataka, Bengaluru, 560074, India; Nagaraju K., CIIRC, Jothy Institute of Technology, Tataguni, Off Kanakapura Road, Karnataka, Bengaluru, 560082, India; Krishna Mohan M., Department of Sciences and Humanities, Christ (Deemed to be University), School of Engineering and Technology, Mysore Road, Karnataka, Bengaluru, 560074, India