Unlocking the Antimicrobial, Antifungal, and Anticancer Power of Chitosan-Stabilized Silver Nanoparticles
- Title
- Unlocking the Antimicrobial, Antifungal, and Anticancer Power of Chitosan-Stabilized Silver Nanoparticles
- Creator
- Ann Maria C.G.; Agnihotri A.S.; Fatima T.; Hameed S.; Krishnamoorthy G.; Nidhin M.
- Description
- Silver nanoparticles (AgNPs) have become a research focus due to its antimicrobial, anticancer applications and cost-effective properties. In this study the effectiveness of green synthesis of NPs using biological macromolecule chitosan which isacting as a reducingcum stabilizing agent is carried out. An in-depth analysis of the synthesized AgNPs was conducted using a variety of sophisticatedcharacterization techniques such as UV-visible spectroscopy, particle size analysis, zeta potentialmeasurements, transmission electron microscopy (TEM), photoluminescence, and Fourier transform infrared (FTIR) spectroscopy. The antimicrobialactivity of the formulated AgNPs were inspected against two human pathogenic strains. In the antimicrobial activity, the synthesized AgNPs exhibited a reduction in the growth of both themicrobes. The minimum inhibitory concentration (MIC) of 1.22 M was observed for both Candida albicans and Mycobacterium smegmatis. Consequently, AgNPs may be used as an opportunity for modern-day antibiotics to treat infections due to human pathogens. Antiproliferative analysis revealed that AgNPs showed antiproliferative characteristics against MDA-MB-231 cells compared to the control. Such AgNPs have an anticancer effect and are likely to be used as smart drug delivery mediators to treat late-stage cancer. 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- Source
- BioNanoScience, Vol-13, No. 4, pp. 1933-1943.
- Date
- 2023-01-01
- Publisher
- Springer
- Subject
- Candida; Chitosan-stabilized silver nanoparticles; Green synthesis; MDA-MB-231 cells; Mycobacterium
- Coverage
- Ann Maria C.G., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Agnihotri A.S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Fatima T., Amity Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurugram, 122413, India; Hameed S., Amity Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurugram, 122413, India; Krishnamoorthy G., Muthayammal Centre for Advanced Research (MCAR) & Department of Biochemistry, Muthayammal College of Arts and Science (Affiliated to Periyar University, Salem), Namakkal District, Tamil Nadu, Rasipuram, 637408, India; Nidhin M., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 21911630
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Ann Maria C.G.; Agnihotri A.S.; Fatima T.; Hameed S.; Krishnamoorthy G.; Nidhin M., “Unlocking the Antimicrobial, Antifungal, and Anticancer Power of Chitosan-Stabilized Silver Nanoparticles,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/13939.