Biogenic Synthesis of Zinc Oxide Nanoparticles Mediated by the Extract of Terminalia catappa Fruit Pericarp and Its Multifaceted Applications
- Title
- Biogenic Synthesis of Zinc Oxide Nanoparticles Mediated by the Extract of Terminalia catappa Fruit Pericarp and Its Multifaceted Applications
- Creator
- Fernandes C.A.; Jesudoss M N.; Nizam A.; Krishna S.B.N.; Lakshmaiah V.V.
- Description
- Zinc oxide nanoparticles (ZnO-NPs) were biosynthesized by using the pericarp aqueous extract from Terminalia catappa Linn. These NPs were characterized using various analytical techniques such as X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, ultraviolet (UV) spectroscopy, dynamic light scattering (DLS), and scanning electron microscopy (SEM), and XRD studies of the nanoparticles reported mean size as 12.58 nm nanocrystals with highest purity. Further SEM analysis emphasized the nanoparticles to be spherical in shape. The functional groups responsible for capping and stabilizing the NPs were identified with FTIR studies. DLS studies of the synthesized NPs reported ? potential as ?10.1 mV and exhibited stable colloidal solution. These characterized ZnO-NPs were evaluated for various biological applications such as antibacterial, antifungal, antioxidant, genotoxic, biocompatibility, and larvicidal studies. To explore its multidimensional application in the field of medicine. NPs reported a potential antimicrobial activity at a concentration of 200 ?g/mL against bacterial strains in the decreasing order of Streptococcus pyogenes > Streptococcus aureus > Streptococcus typhi > Streptococcus aeruginosa and against the fungi Candida albicans. In vitro studies of RBC hemolysis with varying concentrations of NPs confirm their biocompatibility with IC50 value of 211.4 ?g/mL. The synthesized NPs DPPH free radical scavenging activity was examined to extend their antioxidant applications. The antiproliferation and genetic toxicity were studied with meristematic cells of Allium cepa reported with mitotic index (MI index) of 1.2% at the concentration of 1000 ?g/mL. NPs exhibited excellent Larvicidal activity against Culex quinquefasciatus larvae with the highest mortality rate as 98% at 4 mg/L. Our findings elicit the therapeutic potentials of the synthesized zinc oxide NPs. 2023 The Authors. Published by American Chemical Society
- Source
- ACS Omega, Vol-8, No. 42, pp. 39315-39328.
- Date
- 2023-01-01
- Publisher
- American Chemical Society
- Coverage
- Fernandes C.A., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bangalore, 560029, India; Jesudoss M N., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bangalore, 560029, India; Nizam A., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bangalore, 560029, India; Krishna S.B.N., Department of Biomedical and Clinical Technology, Durban University of Technology, Durban, 4000, South Africa; Lakshmaiah V.V., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bangalore, 560029, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 24701343
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Fernandes C.A.; Jesudoss M N.; Nizam A.; Krishna S.B.N.; Lakshmaiah V.V., “Biogenic Synthesis of Zinc Oxide Nanoparticles Mediated by the Extract of Terminalia catappa Fruit Pericarp and Its Multifaceted Applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 26, 2025, https://archives.christuniversity.in/items/show/13973.