An Efficient Copper-Catalyzed Regioselective One-Pot Synthesis of Pyrido[1,2-a]benzimidazole and Its Derivatives
- Title
- An Efficient Copper-Catalyzed Regioselective One-Pot Synthesis of Pyrido[1,2-a]benzimidazole and Its Derivatives
- Creator
- Kommuri V.C.; Vijayan A.; Pawar L.; Arunachalampillai A.
- Description
- A facile and effectual regioselective one-pot synthesis protocol has been developed for the construction of pyrido[1,2-a]benzimidazole and its derivatives using Copper(I) bromide as the catalyst, 1,10-phenanthroline as ligand, and K3PO4 (Tripotassium phosphate) as the base in Dimethyl sulfoxide as solvent at 110 C for 12 h. The reaction conditions were optimized by screening various copper catalysts, ligands, solvents, and bases. The substrate scope of the reaction was also carried out with electron-withdrawing and donating functional groups to prepare novel functionalized regioselective benzimidazole compounds in good to excellent yields. All the isolated compounds were characterized by 1H, 13C, and 19F NMR. 2023 Wiley-VCH GmbH.
- Source
- ChemistrySelect, Vol-8, No. 39
- Date
- 2023-01-01
- Publisher
- John Wiley and Sons Inc
- Subject
- benzimidazole; C-N bond formation; Cu(I)Br; intermolecular cyclization; one-pot synthesis; Ullman coupling
- Coverage
- Kommuri V.C., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, India, Syngene International Limited, Bommasandra Industrial Area, Bengaluru, 560099, India; Vijayan A., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, India; Pawar L., Syngene International Limited, Bommasandra Industrial Area, Bengaluru, 560099, India; Arunachalampillai A., Syngene International Limited, Bommasandra Industrial Area, Bengaluru, 560099, India
- Rights
- Restricted Access
- Relation
- ISSN: 23656549
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Kommuri V.C.; Vijayan A.; Pawar L.; Arunachalampillai A., “An Efficient Copper-Catalyzed Regioselective One-Pot Synthesis of Pyrido[1,2-a]benzimidazole and Its Derivatives,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 26, 2025, https://archives.christuniversity.in/items/show/13977.