Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Marine brown algae (Sargassum wightii) derived 9-hydroxyhexadecanoic acid: A promising inhibitor of ?-amylase and ?-glucosidase with mechanistic insights from molecular docking and its non-target toxicity analysis Subject The topic of the resource ADME; In silico docking; Palmitic acid; Sargassum wightii; toxicity analysis; ?-amylase; ?-glucosidase Description An account of the resource Jeopardized glucose hemostasis leads to cronic metaboic disorder like Diabetes mellitus and it is predicted to occur in ?700 million people in the coming 20 years. Our study aims to isolate Palmitic acid (C16H32O3), 9-Hydroxyhexadecanoic acid metabolite from Sargassum wightii to inhibit alpha-amylase and alpha-glucosidase to reduce postprandial hyperglycemia and decline the risk of diabetes. High docking score of palmitic acid with both ?-amylase and ?-glucosidase is observed in in-silico molecular docking analysis, in comparison to commercially available drug acarbose. The three hydrogen bond in palmitic acid interacts with the important amino acids like Arg195, Lys200 and Asp300 in Glide XP docking mode for alpha-amylase. For ?-glucosidase, quantum-polarized ligand docking (QPLD) was used with similar three hydrogen bond interactions. Both docking studies showed significant binding interaction of palmitic acid with ?-amylase (?5.66 and ?5.14 (Kcal/mol)) and with ?-glucosidase (?4.52 and ?3.51(Kcal/mol)) with respect to the standard, acarbose docking score. The bioactive palmitic acid isolated from the brown alga, Sargassum wightii is already seen to inhibit digestive enzyme with non-target property in Artemia nauplii and zebra fish embryos. Further studies are required to investigate its role in in vivo antidiabetic effects due to its non-toxic and digestive enzyme inhibitory properties. It can be recommended in additional pharmaceutical studies to develop novel therapeutics to manage diabetes mellitus. 2023 SAAB Creator An entity primarily responsible for making the resource Paramasivam D.; Meyyazhagan A.; Thiyagarajulu N.; Arumugasamy K.; Balasubramanian B.; Alanazi A.M.; Rengasamy K.R.R. Source A related resource from which the described resource is derived South African Journal of Botany, Vol-161, pp. 627-637. Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.sajb.2023.08.064" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.sajb.2023.08.064</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85170100231&amp;doi=10.1016%2Fj.sajb.2023.08.064&amp;partnerID=40&amp;md5=12c402062ba7f5452674739559bec46e" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85170100231&amp;doi=10.1016%2fj.sajb.2023.08.064&amp;partnerID=40&amp;md5=12c402062ba7f5452674739559bec46e</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 2546299; CODEN: SAJBD Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Paramasivam D., Department of Life Science, Kristu Jayanti College (Autonomous), Affiliated to Bengaluru North University, Karnataka, Bengaluru, 560077, India; Meyyazhagan A., Department of Life Science, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560076, India; Thiyagarajulu N., Department of Life Science, Kristu Jayanti College (Autonomous), Affiliated to Bengaluru North University, Karnataka, Bengaluru, 560077, India; Arumugasamy K., Department of Zoology, Thiagarajar College, Tamil Nadu, Madurai, 625009, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Alanazi A.M., Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; Rengasamy K.R.R., Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa