Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Delayed in sensorimotor reflex ontogeny, slow physical growth, and impairments in behaviour as well as dopaminergic neuronal death in mice offspring following prenatally rotenone administration Subject The topic of the resource cognitive impairment; physical milestone; prenatally; rotenone; sensorimotor development Description An account of the resource The environment is varying day by day with the introduction of chemicals such as pesticides, most of which have not been effectively studied for their influence on a susceptible group of population involving infants and pregnant females. Rotenone is an organic pesticide used to prepare Parkinson's disease models. A lot of literature is available on the toxicity of rotenone on the adult brain, but to the best of our knowledge, effect of rotenone on prenatally exposed mice has never been investigated yet. Therefore, the recent work aims to evaluate the toxic effect of rotenone on mice, exposed prenatally. We exposed female mice to rotenone at the dose of 5mg/Kg b.w. throughout the gestational period with oral gavage. We then investigated the effects of rotenone on neonate's central nervous systems as well as on postnatal day (PD) 35 offspring. In the rotenone group, we observed slow physical growth, delays in physical milestones and sensorimotor reflex in neonates and induction of anxiety and impairment in cognitive performances of offspring at PD-35. Additionally, immunohistochemical analysis revealed a marked reduction in TH-positive neurons in substantia nigra. Histological examination of the cerebellum revealed a decrease in Purkinje neurons in the rotenone exposed group as compared to the control. The data from the study showed that prenatally exposure to rotenone affects growth, physical milestones, neuronal population and behaviour of mice when indirectly exposed to the offspring through their mother. This study could provide a great contribution to researchers to find out the molecular mechanism and participating signalling pathway behind these outcomes. 2023 International Society for Developmental Neuroscience. Creator An entity primarily responsible for making the resource Jain J.; Hasan W.; Jat D.; Biswas P.; Yadav R.S. Source A related resource from which the described resource is derived International Journal of Developmental Neuroscience, Vol-83, No. 6, pp. 518-531. Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/jdn.10282" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/jdn.10282</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162092257&amp;doi=10.1002%2Fjdn.10282&amp;partnerID=40&amp;md5=f073493b8ec790532891e78b3a3eed11" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162092257&amp;doi=10.1002%2fjdn.10282&amp;partnerID=40&amp;md5=f073493b8ec790532891e78b3a3eed11</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 7365748; PubMed ID: 37337287; CODEN: IJDND Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jain J., Neuroscience Research Lab, School of Biological Sciences, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, India; Hasan W., Neurology Department, Harward Medical School, Harvard Medical School, Boston, United States; Jat D., Neuroscience Research Lab, School of Biological Sciences, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, India; Biswas P., Department of Life Sciences, Christ (Deemed-to-be University), Bangalore, India; Yadav R.S., School of Forensic Science, National Forensic Sciences University, Bhopal, India