Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Parental Psychological Distress of Missed Diagnosis of Down Syndrome at Antenatal Screening: A Rare, but Still Real Occurrence-A Case Report and Review of Literature Subject The topic of the resource False-negative results; Noninvasive prenatal test; Prenatal screening; Psychological effects; Trisomy 21 Description An account of the resource Introduction: Prenatal screening programs are important components for pregnant women care and are often linked with grief and shock based on gestational age or the diagnosis. Lower/no sensitivity is also associated with these screening programs leading to providing false-negative outputs. Case Presentation: Present work shows a case of missed antenatal diagnosis of Down syndrome and its persistant medical and psychological impact on the family members. We have also discussed the relevant economic and medical-legal issues related to the context and aimed to maintain an adequate awareness among healthcare to discuss properly these investigations (difference between screening and diagnostic testing), their possible outcome (chances of false results) and enabled the pregnant women/couple to take informed decision on early pregnancy. Conclusion: These programs are considered as routine clinical practice in many countries from last few years and are necessary to assess the pros and cons of these programs. One of the prime cons involves the likeliness of obtaining a false-negative result due to lack of 100% sensitivity and specificity. 2023 S. Karger AG, Basel. Creator An entity primarily responsible for making the resource Giuseppe Macri P.; Tosto V.; Tsibizova V.; Meyyazhagan A.; Di Renzo G.C. Source A related resource from which the described resource is derived Fetal Diagnosis and Therapy, Vol-50, No. 3, pp. 175-178. Publisher An entity responsible for making the resource available S. Karger AG Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1159/000530332" target="_blank" rel="noreferrer noopener">https://doi.org/10.1159/000530332</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85169188088&amp;doi=10.1159%2F000530332&amp;partnerID=40&amp;md5=75a6dd6508373076a4c80e9a149a8592" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85169188088&amp;doi=10.1159%2f000530332&amp;partnerID=40&amp;md5=75a6dd6508373076a4c80e9a149a8592</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 10153837; PubMed ID: 36966537; CODEN: FDTHE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Giuseppe Macri P., Department of Forensic Medicine of South Tuscany, Ospedali Riuniti di Arezzo, Arezzo, Italy; Tosto V., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy; Tsibizova V., International School PREIS, Firenze, Italy; Meyyazhagan A., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy, International School PREIS, Firenze, Italy, Department of Life Science, Christ University, Bengaluru, India; Di Renzo G.C., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy, International School PREIS, Firenze, Italy, IE Sechenov State University Medical School, Moscow, Russian Federation