ItemArticle

Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms

Title
Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms
Creator
Kumar V.; Sharma N.; Sharma P.; Pasrija R.; Kaur K.; Umesh M.; Thazeem B.
Description
Endocrine disrupting compounds are the chemicals which mimics the natural endocrine hormones and bind to the receptors made for the hormones. Upon binding they activate the cascade of reaction which leads to permanent activating of the signalling cycle and ultimately leads to uncontrolled growth. Pesticides are one of the endocrine disrupting chemicals which cause cancer, congenital birth defects, and reproductive defects in non-target organisms. Non-target organisms are keen on exposing to these pesticides. Although several studies have reported about the pesticide toxicity. But a critical analysis of pesticide toxicity and its role as endocrine disruptor is lacking. Therefore, the presented review literature is an endeavour to understand the role of the pesticides as endocrine disruptors. In addition, it discusses about the endocrine disruption, neurological disruption, genotoxicity, and ROS induced pesticide toxicity. Moreover, biochemical mechanisms of pesticide toxicity on non-target organisms have been presented. An insight on the chlorpyrifos toxicity on non-target organisms along with species names have been presented. 2023 Elsevier Inc.
Source
Toxicology and Applied Pharmacology, Vol-474
Date
2023-01-01
Publisher
Academic Press Inc.
Subject
Biochemical mechanisms; Endocrine disruptors; Genotoxicity; Neurotoxicity; Non-target toxicity
Coverage
Kumar V., Bioconversion and Tissue Engineering Laboratory, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai, 602105, India; Sharma N., Metagenomics and Bioprocess Design Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India; Sharma P., Department of Biochemistry, Maharshi Dayanand University, Haryana, Rohtak, 124001, India; Pasrija R., Department of Biochemistry, Maharshi Dayanand University, Haryana, Rohtak, 124001, India; Kaur K., Punjab Agricultural University, Institute of Agriculture, Gurdaspur, 143521, India; Umesh M., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Thazeem B., Waste Management Division, Integrated Rural Technology Centre (IRTC), Kerala, Palakkad, 678592, India
Rights
All Open Access; Bronze Open Access
Relation
ISSN: 0041008X; PubMed ID: 37414290; CODEN: TXAPA
Format
Online
Language
English
Type
Article

Collection

Articles

Citation

Kumar V.; Sharma N.; Sharma P.; Pasrija R.; Kaur K.; Umesh M.; Thazeem B., “Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/14116.

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