Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Selective Excited-State Intramolecular-Proton-Transfer (ESIPT) Sensor for Copper(II) Based on Chelation-Enhanced Quenching and Off-On Detection of Amino Acids Subject The topic of the resource amino acids; chelation; ESIPT; fluorescence; ratiometry Description An account of the resource We report the synthesis of 2-(4,5-diphenyl-1H-imidazole-2-yl)phenol (TPI-9) as an interesting fluorescent molecule displaying Excited-State Intramolecular-Proton-Transfer (ESIPT) with stokes shift of 120 nm. Phenolic compounds with the ability to form intramolecular hydrogen bonds and subsequent proton transfer are known as ESIPT fluorophores. Proton accepting ability can increase significantly by tailoring electron-donating groups. With the assistance of an environment-friendly organocatalyst, 10-camphor sulfonic acid (10-CSA), TPI-9 was synthesized to introduce substituents with electron-donating abilities to develop an efficient ESIPT mechanism. Factors influencing the emission, such as solvent, pH, and metal ions, are investigated. Quenching of fluorescence by Cu2+ through chelation enhancement quenching effect with a high selectivity allowed the establishment of a Cu2+ sensor with an LoD of 0.57 ppm and a ratiometric estimation with an LoD of 0.73 ppm. Metal binding (2 : 1) stoichiometry and quenching constant (0.0072 mol?1s?1) are calculated from Job's and Stern-Volmer plots. Density functional theory (DFT) calculations are in accordance with the experimental results. Competitive replacement of TPI-9 by amino acids restores ESIPT, consequently, the fluorescence. Thus, an off-on fluorescence sensor for amino acid estimation is developed under 1 minute incubation. A linear relationship between amino acid concentration and fluorescence intensity is in 0-20 ?g/mL range, and the LoD is less than 2.2 ?g/mL. 2023 Wiley-VCH GmbH. Creator An entity primarily responsible for making the resource Devasia J.; Joy F.; Nizam A. Source A related resource from which the described resource is derived Chemistry - A European Journal, Vol-29, No. 25 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/chem.202203652" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/chem.202203652</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150635996&amp;doi=10.1002%2Fchem.202203652&amp;partnerID=40&amp;md5=91ca8a52442f09e3d2b8039c2a01004a" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150635996&amp;doi=10.1002%2fchem.202203652&amp;partnerID=40&amp;md5=91ca8a52442f09e3d2b8039c2a01004a</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 9476539; PubMed ID: 36750756; CODEN: CEUJE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Devasia J., Department of Chemistry, CHRIST (Deemed to be University) Hosur road, DRC post, Bangalore, 560029, India; Joy F., Department of Chemistry, CHRIST (Deemed to be University) Hosur road, DRC post, Bangalore, 560029, India; Nizam A., Department of Chemistry, CHRIST (Deemed to be University) Hosur road, DRC post, Bangalore, 560029, India