Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A concise route to fused tetrazolo scaffolds through 10-camphor sulfonic acid auto-tandem homogeneous catalysis and mechanistic investigation Subject The topic of the resource 10-CSA; Aminotetrazole; Auto-tandem reactions; Bronsted acid; DFT; Tetrazolo pyrimidine; Tetrazolo quinazoline Description An account of the resource 10-Camphor sulfonic acid (10-CSA) as an organo-catalyst has gained interest due to its versatile solubility and easiness of handling. This work reports a simple synthetic method through non-classical Biginelli for the construction of tetrazolo pyrimidine (4a-m) and quinazolines (4a?-o?). Azolopyrimidines and quinazolines are of great pharmaceutical importance. Numerous compounds are currently in use for the treatment of different diseases. Therefore their synthesis is industrially inevitable. Employing aldehydes, 1,3-dicarbonyls, and 5-Aminotetrazole, we report eco-friendly, cost-effective catalysis through a tandem reaction catalyzed by the 10-CSA that gave excellent yields, 7095 % for tetrazolo quinazoline and 4576 % tetrazolo pyrimidines respectively. The homonuclear NOESY analysis confirms the selective formation of one isomer. All the compounds are characterised by 1H NMR, 13C NMR, and MS. Investigation of the reaction mechanism by both experimental and theoretical studies provides evidence. Mechanism of the reaction was also explained utilizing the information from mass spectrometry monitoring. DFT calculation carried out at PBEPBE (Perdew-Burke-Ernzerhof) functional and 6-31G (d,p) basis set level of theory of the various intermediates observed supports the experimental evidence. 2023 Elsevier B.V. Creator An entity primarily responsible for making the resource Devasia J.; Nizam A.; Muthukumar D.; Pillai R.S.; Joy F. Source A related resource from which the described resource is derived Journal of Molecular Liquids, Vol-376 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.molliq.2023.121510" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.molliq.2023.121510</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148543054&amp;doi=10.1016%2Fj.molliq.2023.121510&amp;partnerID=40&amp;md5=68031a4dc65537c89bde29e0a11b50f6" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148543054&amp;doi=10.1016%2fj.molliq.2023.121510&amp;partnerID=40&amp;md5=68031a4dc65537c89bde29e0a11b50f6</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 1677322; CODEN: JMLID Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Devasia J., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Nizam A., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Muthukumar D., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Pillai R.S., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Joy F., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India