Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A site-isolated Lewis acidic aluminium and Brsted basic amine sites in the dimeric silsesquioxane cage as a reusable homogeneous bifunctional catalyst for one-pot tandem deacetalization/deketalization-Knoevenagel condensation reactions Description An account of the resource The development of multifunctional catalysts for one-pot tandem reactions is significantly required to attain multiple sequential transformations in a single reactor, which would considerably decrease the number of manipulations demanded for chemical manufacturing in industries. Herein, dimeric silsesquioxane Al-POSS-NH2 (2), a homogenous bifunctional acid-base catalyst containing environmentally friendly robust silica and high chemical and thermal stabilities, permanent catalytic activity, and reusability, was synthesized by the reaction of trisilanol aminopropyl hexaisobutyl-POSS (1) with trimethylaluminium. Al-POSS-NH2 was successfully used as a bifunctional catalyst for one-pot tandem reactions because of the synergism and effective compartmentalization between Lewis acidic aluminium and Brsted basic amine sites (&gt;10.0 in the dimeric silsesquioxane cage, which was confirmed by DFT and QTAIM studies. Subsequently, different acetals were tested to obtain their corresponding benzylidene malononitrile derivatives using Al-POSS-NH2 for the one-pot tandem deacetalization-Knoevenagel condensation reactions and showed high efficiency (&gt;90%) under optimized conditions (DMF, 0.3 mol% catalyst loading and 80 C) with different reaction times. Furthermore, the bifunctional Al-POSS-NH2 catalyst was separated from the reaction mixture via the precipitation method by adding acetonitrile into the reaction mixture and reusing it for five consecutive cycles without losing activity considerably, thus providing the inherent advantage over traditional homogeneous catalysts. In a one-pot tandem deketalization-Knoevenagel condensation reaction for various ketals, the reaction condition was slightly modified by increasing the catalyst loading (0.6 mol%) and reaction time (16 to 24 hours) to acquire better conversion and yield of their desired products. Finally, the present study suggests that the bifunctional POSS might facilitate the rapid development of environmentally friendly and economically feasible catalysts for multistep reactions. 2023 The Royal Society of Chemistry. Creator An entity primarily responsible for making the resource Loganathan P.; Pillai R.S.; Jennifer G A.; Varathan E.; Kesavan M.; Shanmugan S. Source A related resource from which the described resource is derived New Journal of Chemistry, Vol-47, No. 17, pp. 8439-8450. Publisher An entity responsible for making the resource available Royal Society of Chemistry Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d3nj00276d" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d3nj00276d</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85152697506&amp;doi=10.1039%2Fd3nj00276d&amp;partnerID=40&amp;md5=3c66f257b33355b1c97adb04dacc69ff" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85152697506&amp;doi=10.1039%2fd3nj00276d&amp;partnerID=40&amp;md5=3c66f257b33355b1c97adb04dacc69ff</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 11440546; CODEN: NJCHE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Loganathan P., Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603203, India; Pillai R.S., Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603203, India, Department of Chemistry, Christ University, Karnataka, Bangalore, 56029, India; Jennifer G A., Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603203, India; Varathan E., Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603203, India; Kesavan M., Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603203, India; Shanmugan S., Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603203, India