Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SCN1A Genetic Alterations and Oxidative Stress in Idiopathic Generalized Epilepsy Patients: A Causative Analysis in Refractory Cases Subject The topic of the resource Epilepsy; Inflammatory markers; Oxidative stress; Polymorphisms Description An account of the resource Single Nucleotide Polymorphisms (SNPs) have found it be associated with drug resistance in epilepsy. The purpose of this study was to determine the role of SCN1A gene polymorphism in developing drug resistance in idiopathic generalized epilepsy (IGE) patients, along with increased oxidative stress. The study was conducted at a tertiary care hospital in Delhi, India. We recruited 100 patients diagnosed with IGE patients, grouped as drug-resistant and drug-responsive, and then further compared the SCN1A SNP rs10167228 A*/T analysis between the two groups. We utilized the PCR-RFLP technique to investigate the association between polymorphisms and refractory epilepsy. Serum HMGB1 levels were estimated using the ELISA technique to analyze oxidative stress in both groups. rs10167228 A*/T polymorphism genotypes AT and AA genotypes are significantly associated with an increased risk of developing drug resistance. Serum HMGB1, IL-1?, and IL-6 levels were significantly higher in drug-resistant cases, compared to the drug-responsive group. The association of SCN1A gene polymorphisms, in conjunction with raised oxidative stress, may be predictive of the development of drug-resistant epilepsy. The AT and AA genotypes of rs10167228 may pose a risk factor for developing drug-resistant epilepsy. 2023, The Author(s), under exclusive licence to Association of Clinical Biochemists of India. Creator An entity primarily responsible for making the resource Viswas A.; Dabla P.K.; Gupta S.; Yadav M.; Tanwar A.; Upreti K.; Koner B.C. Source A related resource from which the described resource is derived Indian Journal of Clinical Biochemistry Publisher An entity responsible for making the resource available Springer Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s12291-023-01164-x" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s12291-023-01164-x</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178239345&amp;doi=10.1007%2Fs12291-023-01164-x&amp;partnerID=40&amp;md5=500b078b32ff4a7ee9b0c28c225f6b7a" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178239345&amp;doi=10.1007%2fs12291-023-01164-x&amp;partnerID=40&amp;md5=500b078b32ff4a7ee9b0c28c225f6b7a</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 9701915; CODEN: IJCBE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Viswas A., Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India; Dabla P.K., Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India; Gupta S., Department of Neurology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India; Yadav M., Multi-disciplinary Research Unit, Maulana Azad Medical College, New Delhi, India; Tanwar A., Multi-disciplinary Research Unit, Maulana Azad Medical College, New Delhi, India, Manav Rachna International Institute of Research and Studies, Haryana, Faridabad, India; Upreti K., Department of Computer Science, CHRIST (Deemed to be University), Delhi NCR, Ghaziabad, India; Koner B.C., Multi-disciplinary Research Unit, Maulana Azad Medical College, New Delhi, India, Department of Biochemistry, Maulana Azad Medical College, New Delhi, India