Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid

Title

Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid

Creator

Soman G.; M V.; Hegde G.

Description

Graphene oxide based molecularly imprinted polymer was designed by incorporating vinyltrimethoxysilane into the layers of graphene oxide, which was copolymerized with functional monomers such as Itaconic acid (IA) and methyl methacrylate (MMA) was developed via bulk imprinting technique. The prepared polymer was studied for selective sensing the uric acid (UA) in blood serum. The electrode was constructed by modifying bare glassy carbon electrodes with the prepared molecularly imprinted polymer (MIP) via drop cast method. Electrochemical measurements were made by Cyclic voltammetric (CV) and Differential Pulse Voltammetric (DPV) response of the sensor. The physical and chemical properties of the resultant material will be characterized by FTIR spectroscopy, XRD and FESEM. The constructed sensor showed a regression coefficient (R2) of 0.9302 with limit of detection (LOD) of about 0.565 ??M. The developed sensor is reusable without any compromise in its selectivity. All the results confirm that the constructed biosensor requires no pre-treatment of samples and is suitable for real sample analysis. 2023 The Authors

Source

Sensors International, Vol-4

Date

2023-01-01

Publisher

KeAi Communications Co.

Subject

Biosensor; Electrochemistry; Graphene oxide; Uric acid

Coverage

Soman G., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India, Centre for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Bangalore, 560029, India; M V., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India, Centre for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Bangalore, 560029, India; Hegde G., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India, Centre for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Bangalore, 560029, India

Rights

All Open Access; Gold Open Access

Relation

ISSN: 26663511

Format

Online

Language

English

Type

Article

Identifier

https://doi.org/10.1016/j.sintl.2023.100243

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164423124&doi=10.1016%2fj.sintl.2023.100243&partnerID=40&md5=5062d9c5d50146fd16728d2e67408d56