Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Impact on cardioprotective effect of Psidium guajava leaves extract in streptozotocin-induced Wistar mice with molecular in silico analysis Subject The topic of the resource cardiac markers; lysosomal enzymes; mitochondrial enzymes; Psidium guajava Description An account of the resource Cardiovascular disease (CVD) and its complications have been regarded as the leading cause of morbidity and mortality. The drugs available in the market are effective to treat CVD, but with many adverse reactions. Nowadays, herbal products are the attention of researchers because of their less adverse effects. In this study, the cardioprotective effects of ethanolic leaves extract of Psidium guajava Linn. (Guava) (P. guajava) were evaluated in streptozotocin (STZ)-treated animal models. Mice acquired for the study were divided into five groups, each consisting of six mice. The toxin-induced mice were treated with the ethanolic leaves extract of P. guajava (300 mg/ kg body weight [b.w.]). The results were compared to the standard drug (glibenclamide)-treated mice (3 mg/kg b.w.). The following parameters were considered for further investigations: creatine kinase-muscle brain (CK-MB), creatine kinase (CK), troponin, lysosomal, and mitochondrial enzymes. Then the docking study was accomplished. The levels of cardiac marker enzymes and lysosomal enzymes increased significantly in the toxin-induced mice, while the level of mitochondrial enzyme decreased significantly. During treatment with the ethanolic leaves extract of P. guajava, the levels of all parameters were notably reversed to normal range (P &lt; 0.05). Further, in docking analysis, the interaction of compounds, such as alpha-terpineol, cyclopentanecarboxamide, guaiol (a sesquiterpenoid alcohol), 1H-cyclopropanaphthalene, tetracyclotridecan-9-ol, dormin/abscisic acid, and epiglobulol, with the respective protein molecules, evidenced the cardioprotective effect of P. guajava leaves. Hence, it was concluded that the ethanolic leaves extract of P. guajava leaves have a cardioprotective effect. 2023 Codon Publications. Creator An entity primarily responsible for making the resource Manikandan R.; Balamuralikrishnan B.; Boro A.; Karthika P.; Arun M.; Velayuthaprabhu S.; Malaisamy A.; Rengarajan R.L.; Anand A.V. Source A related resource from which the described resource is derived Quality Assurance and Safety of Crops and Foods, Vol-15, No. 2, pp. 209-221. Publisher An entity responsible for making the resource available Codon Publications Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.15586/QAS.V15I2.1261" target="_blank" rel="noreferrer noopener">https://doi.org/10.15586/QAS.V15I2.1261</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160527512&amp;doi=10.15586%2FQAS.V15I2.1261&amp;partnerID=40&amp;md5=7170ca118e0d7b813f4fbdb59b997659" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160527512&amp;doi=10.15586%2fQAS.V15I2.1261&amp;partnerID=40&amp;md5=7170ca118e0d7b813f4fbdb59b997659</a> Rights Information about rights held in and over the resource All Open Access; Hybrid Gold Open Access Relation A related resource ISSN: 17578361 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Manikandan R., Department of Biochemistry, Shrimati Indira Gandhi College, Tamil Nadu, Tiruchirappalli, India; Balamuralikrishnan B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, South Korea; Boro A., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Karthika P., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, India; Arun M., Department of Life Sciences, CHRIST Deemed to be University, Bengaluru, India; Velayuthaprabhu S., Department of Biotechnology, Bharathiar University, Tamil Nadu, Coimbatore, India; Malaisamy A., Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India; Rengarajan R.L., Rashtriya Uchchatar Shiksha Abhiyan (RUSA) Scheme, Madurai Kamaraj University, Tamil Nadu, Madurai, India; Anand A.V., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India