Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In silico studies of viral protein inhibitors of Marburg virus using phytochemicals from Andrographis paniculata Subject The topic of the resource Andrographidine C; Andrographis paniculata; Bisandrographolide A; Marburg virus; toxicity; VP35; VP40 Dimer Description An account of the resource The Marburg virus is a causative agent of Marburg hemorrhagic fever, which was discovered in Marburg, Germany, in 1967. It is a highly contagious and fatal disease transmitted by body fluids. The reservoir host is African fruit bats. Currently, there is no vaccine available to control this disease. Medicinal plants possess many phytochemicals of great therapeutic value. Many have antiviral properties and have been identified as promising drug molecules against various viral diseases proven with an in silico approach. The current research uses the in silico approach to identify the phyto-derived drugs from Andrographis paniculata to treat the Marburg virus. Twenty-four bioactive molecules from the A. paniculata plant were investigated against the targets VP35 and VP40 of Marburg viral proteins using the AutoDock Vina 1.1.2 tool. Out of 24 compounds, Andrographidine C, Andrographidine A, Andrographolactone, and 7-O-methylwogonin showed best docking scores for the target VP40 dimer while Bisandrographolide A, Luteolin Andrographolide, and Andrographiside showed best docking scores with VP35 protein. To determine the druglikeness, pharmacokinetic and pharmacodynamic properties and toxicity for each targets highest docking score compound was assessed using the Swiss absorption, distribution, metabolism, and excretion (ADME) and pkCSM tool. Andrographidine C and Andrographolide performed well in all the parameters of ADME and toxicity. These compounds are recommended as effective inhibitors of VP35 and VP40 of Marburg virus and potential antiviral drugs to treat the hemorrhagic disease. Furthermore, in vitro and in vivo studies can be used to examine the effectiveness and mode of action against the proteins of the Marburg virus. 2023 R. Hariprasath et al Creator An entity primarily responsible for making the resource Hariprasath R.; Akashpriya C.; Lakshmaiah V.V.; Praveen N. Source A related resource from which the described resource is derived Journal of Applied Biology and Biotechnology, Vol-11, No. 1, pp. 222-231. Publisher An entity responsible for making the resource available Open Science Publishers LLP Inc. Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.7324/JABB.2023.110121" target="_blank" rel="noreferrer noopener">https://doi.org/10.7324/JABB.2023.110121</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142254397&amp;doi=10.7324%2FJABB.2023.110121&amp;partnerID=40&amp;md5=739ac9b878a0968a083264a1bf63ce06" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142254397&amp;doi=10.7324%2fJABB.2023.110121&amp;partnerID=40&amp;md5=739ac9b878a0968a083264a1bf63ce06</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 2347212X Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Hariprasath R., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, India; Akashpriya C., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, India; Lakshmaiah V.V., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, India; Praveen N., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, India