A Simple and Efficient Ligand-Free Copper-Catalyzed C-N Bond Formation of Aryl (Hetero) Halides and N-Heteroaryl Amines
CuI; ligand free; N-heteroaryl amines; pyrimidines and pyrazines; Ullman coupling
In this protocol, we report a simple, inexpensive, and user-friendly conventional method for C-N cross coupling between aryl/heteroaryl halides and hetero aryl amines using copper iodide as a catalyst in DMSO as a solvent to prepare pyrimidines and pyrazines derivatives. The reaction conditions were optimized by screening in various copper catalysts and bases. The substrate scope of the reaction was also carried out to prepare novel functionalized N-arylated compounds in good yields. 2021 Taylor & Francis Group, LLC.
Kommuri V.C.; Tadiparthi K.; Pawar L.; Arunachalampillai A.
Polycyclic Aromatic Compounds, Vol-43, No. 1, pp. 665-673.
Kommuri V.C., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Tadiparthi K., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Pawar L., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Arunachalampillai A., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India