Potassium tert-Butoxide-Mediated Synthesis of 2-Aminoquinolines from Alkylnitriles and 2-Aminobenzaldehyde Derivatives
- Title
- Potassium tert-Butoxide-Mediated Synthesis of 2-Aminoquinolines from Alkylnitriles and 2-Aminobenzaldehyde Derivatives
- Creator
- Kishore P.S.; Gujjarappa R.; Putta V.P.R.K.; Polina S.; Singh V.; Malakar C.C.; Pujar P.P.
- Description
- KOtBu mediates the reaction between 2-amino arylcarbaldehydes and benzyl/alkyl cyanides toward the expeditious formation of 2-aminoquinolines under transition-metal-free conditions. The described transformation proceeds through in-situ generated enimine intermediate from benzyl/alkyl cyanides under KOtBu-mediated reaction conditions. The substituted 2-aminoquinolines were realized in excellent yields at room temperature and shorter reaction time. The designed process exhibits operational simplicity and broad functional group tolerance in delivering the products of high significance. 2022 Wiley-VCH GmbH.
- Source
- ChemistrySelect, Vol-7, No. 46
- Date
- 2022-01-01
- Publisher
- John Wiley and Sons Inc
- Subject
- 2-Amino arylcarbaldehydes; 2-Aminoquinolines; Alkyl cyanides; KOtBu; Transition-metal-free
- Coverage
- Kishore P.S., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Gujjarappa R., Department of Chemistry, National Institute of Technology Manipur, Langol, Manipur, Imphal, 795004, India; Putta V.P.R.K., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Polina S., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Singh V., Department of Chemistry, Central University of Punjab, Punjab, Bathinda, 151001, India; Malakar C.C., Department of Chemistry, National Institute of Technology Manipur, Langol, Manipur, Imphal, 795004, India; Pujar P.P., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 23656549
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Kishore P.S.; Gujjarappa R.; Putta V.P.R.K.; Polina S.; Singh V.; Malakar C.C.; Pujar P.P., “Potassium tert-Butoxide-Mediated Synthesis of 2-Aminoquinolines from Alkylnitriles and 2-Aminobenzaldehyde Derivatives,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/14782.