A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions
Epoxidation; Epoxy carbonyls; Flow chemistry; Olefins; Plate reactor
Herein, we report a simple synthetic protocol for selective epoxidation of olefins, monocyclic terpenes, and chalcones using a continuous semi-batch process in good to excellent yields. Mainly, industrial semi-batch epoxidation is an extremely risky process that includes very high safety measures to avoid the accumulation of peroxide species in the reactor during the process, which leads to accidents. To avoid the same, we have established a constant flow reactor protocol for the epoxidation of fore mentioned key synthons using a cyanamide-potassium carbonate catalytic system which helps to reduce the accumulation of the peroxide species, and also yields moderate to high yields of the desired products. The developed methodology was successfully utilized for the epoxidation of a range of aliphatic to aromatic olefins to generate corresponding epoxides. All the products and their structures were examined using 1HNMR, and 13NMR spectroscopy. More importantly, this proposed protocol is recyclable and reproducible where in using similar research conditions. 2022 The Authors
Ramaswamy C.R.; Kopparapu I.; Raykar A.; Kulkarani A.; A V V.S.; Ayyanar S.; Nagarjuna A.; Cheedarala R.K.
https://doi.org/10.1016/j.rineng.2022.100652 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139298792&doi=10.1016%2fj.rineng.2022.100652&partnerID=40&md5=200ef2f621bb14c3fe1523505b5a664e
Ramaswamy C.R., Supramolecular and Organometallic Chemistry Laboratory (SOCL), Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Palkalai Nagar, Tamilnadu, Madurai, 625 021, India; Kopparapu I., Department of Science and Humanities, Chirst University, Bangalore, 560074, India; Raykar A., FlowRHEX, Proburgeon Pvt Ltd, A2-301, Sri Swami Samarth Landmark, Phase 2, Narhe Pune, 411041, India; Kulkarani A., FlowRHEX, Proburgeon Pvt Ltd, A2-301, Sri Swami Samarth Landmark, Phase 2, Narhe Pune, 411041, India; A V V.S., Department of Science and Humanities, Chirst University, Bangalore, 560074, India; Ayyanar S., Supramolecular and Organometallic Chemistry Laboratory (SOCL), Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Palkalai Nagar, Tamilnadu, Madurai, 625 021, India; Nagarjuna A., Department of Chemistry, Jawaharlal Nehru Technological University(JNTU), Kukatpally, Hyderabad, 500 050, India; Cheedarala R.K., Research Institute of Mechatronics, Mechanical Engineering, Changwon National University, Changwondaehak-ro, Ulchang-gu, Changwon-city, 51139, South Korea