Evaluation of Wound Healing Effect of Curcumin Loaded OPL Carbon Nanospheres Embedded Chitosan Membranes
- Title
- Evaluation of Wound Healing Effect of Curcumin Loaded OPL Carbon Nanospheres Embedded Chitosan Membranes
- Creator
- M R.; S J.M.; Velmurugan R.; Hegde G.; Soontarapa K.; Keri R.S.
- Description
- Biowaste-derived carbon biomaterial scaffolds are being used for wound healing and are the focus of interest. Carbon nanospheres derived from oil palm leaves without any catalysts via pyrolysis were loaded with a traditional drug curcumin. The wound healing scaffolds were fabricated on the PP non-woven fabric support using chitosan as the biopolymer matrix. Prepared carbon nanospheres and the scaffolds were characterized using ATR-IR and FESEM techniques. The wettability of scaffolds was examined to ensure the feasible moisture absorption ability, in vitro drug release profile and in vitro antibacterial activity against two strains of bacteria. The in vivo wound healing feature of scaffolds was studied by excision wound model for MRSA infected wound. Measured wound contraction percentage and the bacterial count on wounds at regular time intervals proved that, the scaffold dressed with chitosan and curcumin loaded carbon nanospheres showed an efficient reconstruction of skin through histopathological investigations. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- Source
- Journal of Polymers and the Environment, Vol-30, No. 12, pp. 5190-5201.
- Date
- 2022-01-01
- Publisher
- Springer
- Subject
- Carbon nanospheres; Chitosan; Curcumin; MRSA infection; Wound healing
- Coverage
- M R., Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangaluru, 562112, India; S J.M., Department of Chemistry, AMC Engineering College, Bannerughatta Main Road, Bengaluru, 560083, India; Velmurugan R., Department of Biochemistry, Chulalongkorn University Bangkok, Bangkok, 10330, Thailand; Hegde G., Center for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Bangalore, 560029, India, Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Soontarapa K., Department of Chemical Technology, Faculty of Sciences, Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University, Phayathai Road, Bangkok, 10330, Thailand; Keri R.S., Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangaluru, 562112, India, Organic and Medicinal Chemistry Laboratory, Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Jakkasandra Post Kanakapura Road Ramanagara District, Karnataka, Bengaluru, 562112, India
- Rights
- Restricted Access
- Relation
- ISSN: 15662543; CODEN: JPENF
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
M R.; S J.M.; Velmurugan R.; Hegde G.; Soontarapa K.; Keri R.S., “Evaluation of Wound Healing Effect of Curcumin Loaded OPL Carbon Nanospheres Embedded Chitosan Membranes,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/14834.