Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource CoFe2O4-APTES nanocomposite for the selective determination of tacrolimus in dosage forms: Perspectives from computational studies Subject The topic of the resource APTES; Cobalt ferrite nanoparticles; Dosage forms; Electrochemical determination; Tacrolimus Description An account of the resource An innovative and cost effective electrochemical sensor was fabricated to determine tacrolimus (TAC) in pharmaceutical samples. In the present study, cobalt ferrite nanoparticles (CFO) were synthesized hydrothermally using chitosan as the template and were further functionalized using (3-Aminopropyl) triethoxysilane (APTES). The synthesized CFO were characterized using various analytical techniques such as X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry and high- resolution transmission electron microscopy. The CFO and CFO-APTES were further drop-casted on to the glassy carbon electrode (CFO-NH2/GCE) for the electrochemical determination of TAC. Under the optimum conditions, the CFO-NH2/GCE showed a very low detection limit of 0.03 nM with a high sensitivity of 21,448 ?A?M?1cm?2 and a wide linear TAC concentration range of 0.14 nM 75.83 nM. The proposed sensor showed good sensitivity, selectivity, reproducibility and stability for the sensing of TAC and this has been demonstrated by analysing TAC in different dosage forms. This is the first study to report the interaction of CFO-TAC and CFO-NH2-TAC at the electrode/electrolyte interface. To support the experimental findings qualitatively, extensive density functional theory simulations were carried out to study the interaction at the interface. Hence the proposed sensor is very selective and sensitive towards the detection of TAC. 2022 Elsevier B.V. Creator An entity primarily responsible for making the resource Agnihotri A.S.; Ann Maria C.G.; Varghese A.; Mane P.; Chakraborty B.; M N. Source A related resource from which the described resource is derived Surfaces and Interfaces, Vol-35 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.surfin.2022.102406" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.surfin.2022.102406</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140406930&amp;doi=10.1016%2Fj.surfin.2022.102406&amp;partnerID=40&amp;md5=d6149c7ec662429fcf64be9caf0bd04e" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140406930&amp;doi=10.1016%2fj.surfin.2022.102406&amp;partnerID=40&amp;md5=d6149c7ec662429fcf64be9caf0bd04e</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 24680230 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agnihotri A.S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Ann Maria C.G., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Varghese A., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Mane P., Seismology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India; Chakraborty B., High pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India, Homi Bhabha National Institute, Mumbai, India; M N., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India