Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Phyllanthus Emblica Extract Protects the Rat Liver Cells Against the Toxicity of Monosodium Glutamate: Experimental Evidence Subject The topic of the resource Antioxidants; Monosodium glutamate; Oxidative stress; Phyllanthus emblica; Vitamin C; Vitamin E Description An account of the resource Background: Monosodium glutamate (MSG), used widely in the food industry, is a threat to the public health. We investigated whether the MSG administration depletes non-enzymatic antioxidants, i.e., vitamins C and E in the liver of Wistar albino rats. We also examined the restorative effect of the ethanolic extract of Phyllanthus emblica (P. emblica). Methods: Wistar albino rats (n=42) were adapted and then randomly divided into seven groups of: 1) control, 2, 3, 4) MSG treatment, and 5, 6, 7) combined MSG and P. emblica extract treatment. All rat groups were treated daily for 120 days. They were orally administered either MSG alone or MSG plus the extract combined. The rats were then sacrificed and the liver was harvested from each group, and homogenized to examine the levels of vitamins C and E in the liver, using RP-HPLC method. Results: The vitamins C and E levels significantly declined (P&lt;0.05) in the liver of MSG treated groups compared to those of the control rats. The combined treatment (extract + MSG) at low and moderate doses restored the vitamin C levels but it restored vitamin E only at the low dose (P&lt;0.05). Conclusions: This study clearly demonstrated the deterioration of non-enzymatic antioxidants, i.e., vitamins C and E in the rats' liver after chronic exposure to MSG. The findings support the toxic effect and oxidative stress due to MSG exposure to the liver and the beneficial effect of the extract of P. emblica that inhibits the MSG's harmful effect on the liver. The Author(s), 2022. Creator An entity primarily responsible for making the resource Thangachi S.B.; Mokhasi V.S.; Sathyamoorthy Y.K.; Pinnelli V.B.K.; Chiruthanur S. Source A related resource from which the described resource is derived Iranian Journal of Toxicology, Vol-16, No. 3 Publisher An entity responsible for making the resource available Arak University of Medical Sciences Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.32598/IJT.16.3.923.1" target="_blank" rel="noreferrer noopener">https://doi.org/10.32598/IJT.16.3.923.1</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133018365&amp;doi=10.32598%2FIJT.16.3.923.1&amp;partnerID=40&amp;md5=5576424f77523903e2f902c41a0bcd73" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133018365&amp;doi=10.32598%2fIJT.16.3.923.1&amp;partnerID=40&amp;md5=5576424f77523903e2f902c41a0bcd73</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 20082967 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thangachi S.B., Department of Anatomy, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Karnataka, Bengaluru, India; Mokhasi V.S., Department of Anatomy, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Karnataka, Bengaluru, India; Sathyamoorthy Y.K., Department of Psychology, Faculty of Social Sciences, CHRIST, Deemed to be University, Karnataka, Bengaluru, India; Pinnelli V.B.K., Department of Biochemistry, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Karnataka, Bengaluru, India; Chiruthanur S., Department of Anatomy, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Karnataka, Bengaluru, India