Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study Subject The topic of the resource Coronavirus; COVID-19; In silico study; Omicron; Spike-RBD Description An account of the resource Background: Omicron (B.1.1.529), a variant of SARS-CoV-2 is currently spreading globally as a dominant strain. Due to multiple mutations at its Spike protein, including 15 amino acid substitutions at the receptor binding domain (RBD), Omicron is a variant of concern (VOC) and capable of escaping vaccine generated immunity. So far, no specific treatment regime is suggested for this VOC. Methods: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex. Further, molecular dynamic simulation was performed between Crcumin and Omicron S protein to evaluate the structural stability of the complex in the physiological environment and compared with that of the control drug Chloroquine. Results: Curcumin, among seven phytochemicals, was found to have the most substantial inhibitory potential with Omicron S protein. Further, it was found that curcumin could disrupt the Omicron S-hACE2 complex. The molecular dynamic simulation demonstrated that Curcumin could form a stable structure with Omicron S in the physiological environment. Conclusion: To conclude, Curcumin can be considered as a potential therapeutic agent against the highly infectious Omicron variant of SARS-CoV-2. 2022 Elsevier Ltd Creator An entity primarily responsible for making the resource Nag A.; Banerjee R.; Paul S.; Kundu R. Source A related resource from which the described resource is derived Computers in Biology and Medicine, Vol-146 Publisher An entity responsible for making the resource available Elsevier Ltd Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.compbiomed.2022.105552" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.compbiomed.2022.105552</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129268184&amp;doi=10.1016%2Fj.compbiomed.2022.105552&amp;partnerID=40&amp;md5=1e18617704cc4ac5a219c350253f632b" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129268184&amp;doi=10.1016%2fj.compbiomed.2022.105552&amp;partnerID=40&amp;md5=1e18617704cc4ac5a219c350253f632b</a> Rights Information about rights held in and over the resource All Open Access; Green Open Access Relation A related resource ISSN: 104825; PubMed ID: 35508082; CODEN: CBMDA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nag A., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Banerjee R., School of Biological and Environmental Sciences, Shoolini University, Himachal Pradesh, Solan, 173229, India; Paul S., School of Biotechnology, Presidency University, Canal Bank Rd, DG Block, Action Area 1D, West Bengal, New Town, 700156, India; Kundu R., Department of Botany, University of Calcutta, West Bengal, Kolkata, 700019, India