Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Dual-mode chemosensor for the fluorescence detection of zinc and hypochlorite on a fluorescein backbone and its cell-imaging applications Description An account of the resource Fluorescein coupled with 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one (FAD) was synthesized for the selective recognition of Zn2+ over other interfering metal ions in acetonitrile/aqueous buffer (1 : 1). Interestingly, there was a significant fluorescence enhancement of FAD in association with Zn2+ at 426 nm by strong chelation-induced fluorescence enhancement (CHEF) without interrupting the cyclic spirolactam ring. A binding stoichiometric ratio of 1 : 2 for the ligand FAD with metal Zn2+ was proven by a Jobs plot. However, the cyclic spirolactam ring was opened by hypochlorite (OCl?) as well as oxidative cleavage of the imine bond, which resulted in the emission enhancement of the wavelength at 520 nm. The binding constant and detection limit of FAD towards Zn2+ were determined to be 1 104 M?1 and 1.79 ?M, respectively, and the detection limit for OCl? was determined as 2.24 ?M. We introduced here a dual-mode chemosensor FAD having both the reactive functionalities for the simultaneous detection of Zn2+ and OCl? by employing a metal coordination (Zn2+) and analytes (OCl?) induced chemodosimetric approach, respectively. Furthermore, for the practical application, we studied the fluorescence imaging inside HeLa cells by using FAD, which demonstrated it can be very useful as a selective and sensitive fluorescent probe for zinc. 2022 The Royal Society of Chemistry. Creator An entity primarily responsible for making the resource Maity S.; Maity A.C.; Das A.k.; Bhattacharyya N. Source A related resource from which the described resource is derived Analytical Methods, Vol-14, No. 28, pp. 2739-2744. Publisher An entity responsible for making the resource available Royal Society of Chemistry Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1039/d2ay00855f" target="_blank" rel="noreferrer noopener">https://doi.org/10.1039/d2ay00855f</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133558251&amp;doi=10.1039%2Fd2ay00855f&amp;partnerID=40&amp;md5=6c846cf91446e4061043d990cdf3f1a9" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133558251&amp;doi=10.1039%2fd2ay00855f&amp;partnerID=40&amp;md5=6c846cf91446e4061043d990cdf3f1a9</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 17599660; PubMed ID: 35775440 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Maity S., Department of Applied Sciences, Haldia Institute of Technology, Hatiberia, West Bengal, Haldia, 721657, India; Maity A.C., Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, West Bengal, Howrah, 711103, India; Das A.k., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bengaluru, 560029, India; Bhattacharyya N., Panskura Banamali College, Purba Medinipur, West Bengal, India