Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2
- Title
- Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2
- Creator
- Vadivalagan C.; Shitut A.; Kamalakannan S.; Chen R.-M.; Serrano-Aroca ; Mishra V.; Aljabali A.A.A.; Singh S.K.; Chellappan D.K.; Gupta G.; Dua K.; El-Tanani M.; Tambuwala M.M.; Krishnan A.
- Description
- Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy. 2022 The Authors
- Source
- Cellular Signalling, Vol-95
- Date
- 2022-01-01
- Publisher
- Elsevier Inc.
- Subject
- Artificial miRNA; COVID19 mutant; Exosomes; Inhibition; Transcription
- Coverage
- Vadivalagan C., Graduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei, 110, Taiwan, Department of Biochemistry, AKFA Medical School, AKFA University, Tashkent, Uzbekistan; Shitut A., Department of Life Sciences, Christ University, Nagar, Bangalor, Karnataka, Bhavani, 560029, India; Kamalakannan S., National Center for Disease Control, Ministry of Health and Family Welfare, Government of India, New Delhi, 110054, India; Chen R.-M., Graduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei, 110, Taiwan; Serrano-Aroca , Biomaterials and Bioengineering Lab, Centro de Investigaci Traslacional San Alberto Magno, Universidad Catica de Valencia San Vicente Mtir, Valencia, Spain; Mishra V., School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Punjab, Phagwara, India; Aljabali A.A.A., Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk UniversityFaculty of Pharmacy, Irbid, 21163, Jordan; Singh S.K., School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Punjab, Phagwara, India, Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, 2007, NSW, Australia; Chellappan D.K., School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia; Gupta G., School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, 248007, India; Dua K., School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, 2007, NSW, Australia; El-Tanani M., Pharmacological and Diagnostic Research Centre, Al-Ahliyya Amman University, Faculty of Pharmacy, Amman, Jordan; Tambuwala M.M., School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, United Kingdom; Krishnan A., Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300, South Africa, Department of Chemical Pathology, School of Pathology, National Health Laboratory Services, Bloemfontein, South Africa
- Rights
- All Open Access; Green Open Access; Hybrid Gold Open Access
- Relation
- ISSN: 8986568; PubMed ID: 35461900; CODEN: CESIE
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Vadivalagan C.; Shitut A.; Kamalakannan S.; Chen R.-M.; Serrano-Aroca ; Mishra V.; Aljabali A.A.A.; Singh S.K.; Chellappan D.K.; Gupta G.; Dua K.; El-Tanani M.; Tambuwala M.M.; Krishnan A., “Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/15067.