A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride
- Title
- A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride
- Creator
- Mahesh Kumar A.; Venkateshwarlu R.; Tadiparthi K.; Rao B.V.; Kota Balaji S.K.; Raghunadh A.; Singh S.N.
- Description
- A simple and efficient synthesis of (2S,5S)-5-Hydroxypipecolic acid hydrochloride is reported. The key features of the synthesis involve the asymmetric reduction of ketone using (S)-CBS oxazaborolidine and the use of commercially available methyl pyroglutamate as a starting material.. 2022 Taylor & Francis Group, LLC.
- Source
- Synthetic Communications, Vol-52, No. 6, pp. 827-833.
- Date
- 2022-01-01
- Publisher
- Taylor and Francis Ltd.
- Subject
- (S)-CBS-oxazaborolidine; HCl salt of 5-hydroxypipecolic acid; methyl pyroglutamate; piperidine
- Coverage
- Mahesh Kumar A., Technology Development Center, Custom Pharmaceutical Services, Dr. Reddys Laboratories Ltd, Hyderabad, India; Venkateshwarlu R., Technology Development Center, Custom Pharmaceutical Services, Dr. Reddys Laboratories Ltd, Hyderabad, India, Department of Organic Chemistry and FDW, Andhra University, Visakhapatnam, India; Tadiparthi K., CHRIST (Deemed to be University), Bangalore, India; Rao B.V., AU College of Engineering (A), Andhra University, Visakhapatnam, India; Kota Balaji S.K., Technology Development Center, Custom Pharmaceutical Services, Dr. Reddys Laboratories Ltd, Hyderabad, India; Raghunadh A., Technology Development Center, Custom Pharmaceutical Services, Dr. Reddys Laboratories Ltd, Hyderabad, India; Singh S.N., Technology Development Center, Custom Pharmaceutical Services, Dr. Reddys Laboratories Ltd, Hyderabad, India
- Rights
- Restricted Access
- Relation
- ISSN: 397911; CODEN: SYNCA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Mahesh Kumar A.; Venkateshwarlu R.; Tadiparthi K.; Rao B.V.; Kota Balaji S.K.; Raghunadh A.; Singh S.N., “A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride,” CHRIST (Deemed To Be University) Institutional Repository, accessed April 11, 2025, https://archives.christuniversity.in/items/show/15427.