Visible Light Mediated Organophotoredox-Catalyzed One-Pot Domino Synthesis of Novel 6,7 Disubstituted 1H-Pyrroles
- Title
- Visible Light Mediated Organophotoredox-Catalyzed One-Pot Domino Synthesis of Novel 6,7 Disubstituted 1H-Pyrroles
- Creator
- Govindaraju S.; Tabassum S.
- Description
- The development of environmentally benign protocols to synthesize novel N-heterocycles is vital in the field of synthetic organic chemistry. We herein report a successful one-pot domino synthesis of novel 6,7 disubstituted 1H-pyrroles using substituted phenacyl bromide, barbituric acid/Meldrums acid, aromatic amines catalysed by 5mol% Fluorescein in presence of visible light. This procedure is a useful and adaptable method for the synthesis of pyrroles since it is compatible with a wide range of sensitive functional groups, does not require column chromatography purification. During the reaction, Fluorescein may catalyse the formation of enamine leading to amino alcohol which subsequently undergoes dehydration to give 6,7 disubstituted 1H-pyrroles. All the synthesized derivatives were obtained in 9095% yields and were characterized by 1H, 13C NMR and HRMS (ESI) analysis. Graphical Abstract: [Figure not available: see fulltext.] 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- Source
- Topics in Catalysis
- Date
- 2022-01-01
- Publisher
- Springer
- Subject
- 6,7 disubstituted 1H-pyrrole; Ethanol; Fluorescein; Four-component reaction; Organophotocatalyst; Visible light
- Coverage
- Govindaraju S., Department of Sciences and Humanities, School of Engineering and Technology, CHRIST (Deemed To Be University), Kumbalagodu, Mysore Road, Bengaluru, 560074, India; Tabassum S., Department of Chemistry, Surana College, South End Road, Basavanagudi, Bengaluru, 560004, India
- Rights
- Restricted Access
- Relation
- ISSN: 10225528
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Govindaraju S.; Tabassum S., “Visible Light Mediated Organophotoredox-Catalyzed One-Pot Domino Synthesis of Novel 6,7 Disubstituted 1H-Pyrroles,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/15479.