Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A protoberberine alkaloid based ratiometric pH-responsive probe for the detection of diabetic ketoacidosis Subject The topic of the resource Berberrubine; Diabetic ketoacidosis; Fluorescent probe; pH sensor; Ratiometric Description An account of the resource Herein we report a ratiometric naturally occurring fluorescent pH probe, berberrubine (BBn) for the direct detection of diabetic ketoacidosis (DKA) conditions of patients having type I diabetes mellitus. The photophysical properties of the probe during pH titrations showed remarkable changes in absorption spectra where two absorption bands at 377 and 326 nm have disappeared followed by the emergence of an absorption maxima at 346 nm in highly acidic conditions. In addition, a fluorescence enhancement effect was observed in the alkaline pH, with a bathochromic shift of 33 nm. Moreover, the solution switches the color from light yellow to light pink with the change of pH from acidic to basic. A pKa value of 7.57 and a good linearity between pH 5.09.0 indicate that the probe can be used efficiently for the DKA condition, where pH variations are in the range of 67. The excellent water solubility, photostability, reversibility, and selectivity of BBn make it a potential pH sensing agent for acidic microenvironments. The reversible sensing of pH variations during DKA could be effective in primary detection and diagnosis which can assist in avoiding further complications of acidosis. 2021 Elsevier Ltd Creator An entity primarily responsible for making the resource Meenu M.T.; Cherian A.R.; Sherin D.R.; Nair A.R.; Manojkumar T.K.; Radhakrishnan K.V.; Varghese A. Source A related resource from which the described resource is derived Dyes and Pigments, Vol-194 Publisher An entity responsible for making the resource available Elsevier Ltd Date A point or period of time associated with an event in the lifecycle of the resource 2021-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.dyepig.2021.109636" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.dyepig.2021.109636</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110060284&amp;doi=10.1016%2Fj.dyepig.2021.109636&amp;partnerID=40&amp;md5=b9e85728fd1545295986cd607d8e5515" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110060284&amp;doi=10.1016%2fj.dyepig.2021.109636&amp;partnerID=40&amp;md5=b9e85728fd1545295986cd607d8e5515</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 1437208; CODEN: DYPID Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Meenu M.T., Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, 695019, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; Cherian A.R., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, 560029, India; Sherin D.R., School of Digital Sciences, Kerala University of Digital Sciences, Innovation and Technology, Thiruvananthapuram, 695317, India; Nair A.R., Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, 695019, India; Manojkumar T.K., School of Digital Sciences, Kerala University of Digital Sciences, Innovation and Technology, Thiruvananthapuram, 695317, India; Radhakrishnan K.V., Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, 695019, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; Varghese A., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, 560029, India