Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inhibitory potential of ferula assafoetida extract on L-type calcium channel protein revealed by zebrafish studies and molecular docking Subject The topic of the resource 26-hydroxycholesterol; Cardiotoxic; Embryotoxicity; Ferula assafoetida; Zebrafish Description An account of the resource Ferula assafoetida is a part of many herbal formulations and hence it is pertinent to check the safety of its components specially to growing embryos. Zebrafish (Danio rerio) is considered to be one of the best models to study human embryonic development and metabolic pathways as its genome is fully sequenced and it possesses easily detectable developmental properties. In present study, the embryos of Danio rerio were treated with different concentrations of methanolic extract of Ferula assafoetida (MEFA) and its effects were checked at different post fertilization periods. Decreased heart beat rates, shrinkage of the chorion wall and other developmental abnormalities leading to the death of the embryos were observed. The methanolic extract of Ferula assafoetida was subjected to GC-MS to determine the different compounds present. Cardiotoxicity of these compounds were studied as it is one of the important factors for the retraction of a drug from the market. Molecular docking studies with L-type calcium channel (LTCC), a protein important for cardiac functioning, showed strong binding to the phytochemicals in the extract, with the maximum binding affinity observed with 26-hydroxycholesterol. The study proves that the methanolic extract of Ferula assafoetida contains phytochemicals which have the potential to cause cardiotoxicity in zebrafish embryos by interfering with the functions of LTCC possibly leading to arrhythmia. Altogether, our data suggest that the usage of these extracts in drug formulations should be done with caution. This is also indicative of the possible cytotoxic effect of the extract which could be tapped in the search for anticancer drugs. 2021 Chemical Publishing Co.. All rights reserved. Creator An entity primarily responsible for making the resource Misra S.; Kootery K.P.; Sarojini S. Source A related resource from which the described resource is derived Asian Journal of Chemistry, Vol-33, No. 10, pp. 2353-2359. Publisher An entity responsible for making the resource available Asian Publication Corporation Date A point or period of time associated with an event in the lifecycle of the resource 2021-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.14233/ajchem.2021.23326" target="_blank" rel="noreferrer noopener">https://doi.org/10.14233/ajchem.2021.23326</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115657802&amp;doi=10.14233%2Fajchem.2021.23326&amp;partnerID=40&amp;md5=7beb2448907f8b937dbaa2a6258125c1" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115657802&amp;doi=10.14233%2fajchem.2021.23326&amp;partnerID=40&amp;md5=7beb2448907f8b937dbaa2a6258125c1</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 9707077; CODEN: AJCHE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Misra S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Kootery K.P., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Sarojini S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India