Novel dioxidomolybdenum complexes containing ONO chelators: Synthesis, physicochemical properties, crystal structures, Hirshfeld surface analysis, DNA binding/cleavage studies, docking, and in vitro cytotoxicity
- Title
- Novel dioxidomolybdenum complexes containing ONO chelators: Synthesis, physicochemical properties, crystal structures, Hirshfeld surface analysis, DNA binding/cleavage studies, docking, and in vitro cytotoxicity
- Creator
- Vineetha M.C.; Joy F.; Krishna P. M.; Vinod T.P.; Venkataraman S.K.; Agarwal A.K.; Nair Y.; Kurup M.R.P.
- Description
- A series of dioxidomolybdenum (VI) complexes, [MoO2(ESB)H2O]DMF (1), [MoO2(ESB)MeOH] (2), and [MoO2(ESB)H2O]EtOH (3), containing 3-ethoxysalicylaldehyde benzoylhydrazone have been synthesized and analysed using various spectral and analytical techniques such as elemental analyses, IR spectra, UVVis absorption spectra, X-ray crystallography, and Hirshfeld surface analysis. Based on the elemental and spectral analysis, six-coordinate geometry was assigned for these complexes wherein the hydrazone ligand binds to the metal centre in its dianionic enolate form through ONO donor set. Distorted octahedral geometry of complexes 1 and 2 was evidenced from their crystal structures, which is typical for many cis-dioxido complexes of MoVI. The proligand and the new complexes were examined for their DNA binding, DNA cleavage, and cytotoxic properties. The DNA binding efficiency of the compounds in terms of their binding constants (Kb) of the metal complexes was observed to be 1.3727 105 M?1, 3.0194 104 M?1, and 1.13206 104 M?1 for [MoO2(ESB)H2O]DMF (1), [MoO2(ESB)MeOH] (2), and [MoO2(ESB)H2O]EtOH (3), respectively, indicating that these complexes strongly bind to DNA. To determine the binding interactions of the complexes with DNA and protein (BSA), molecular docking studies were carried out. Gel electrophoresis study reveals the fact that the complexes cleaved supercoiled pUC-18 DNA to nicked form (Form II) in the presence and absence of H2O2. The complexes showed significantly high cytotoxicity against MCF-7 (breast cancer cells). 2021 John Wiley & Sons, Ltd.
- Source
- Applied Organometallic Chemistry, Vol-35, No. 9
- Date
- 2021-01-01
- Publisher
- John Wiley and Sons Ltd
- Subject
- benzoylhydrazone; cytotoxicity; ethidium bromide; Hirshfeld analysis; nuclease activity
- Coverage
- Vineetha M.C., Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, India, Department of Chemistry, Sree Kerala Varma College, Thrissur, India; Joy F., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, India; Krishna P. M., Department of Chemistry, Ramaiah Institute of Technology, Bengaluru, India; Vinod T.P., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, India; Venkataraman S.K., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, India; Agarwal A.K., Discovery Chemistry, Syngene International Limited, Bengaluru, India; Nair Y., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, India; Kurup M.R.P., Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, India, Department of Chemistry, School of Physical Sciences, Central University of Kerala, Periye, Kasaragod, India
- Rights
- Restricted Access
- Relation
- ISSN: 2682605; CODEN: AOCHE
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Vineetha M.C.; Joy F.; Krishna P. M.; Vinod T.P.; Venkataraman S.K.; Agarwal A.K.; Nair Y.; Kurup M.R.P., “Novel dioxidomolybdenum complexes containing ONO chelators: Synthesis, physicochemical properties, crystal structures, Hirshfeld surface analysis, DNA binding/cleavage studies, docking, and in vitro cytotoxicity,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/15675.