Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antioxidant and antigenotoxic properties of Alpinia galanga, Curcuma amada, and Curcuma caesia Subject The topic of the resource Alpinia galanga; Anti-genotoxic; Antioxidants; Curcuma amada; Curcuma caesia; Phytochemicals; Zingiberaceae Description An account of the resource Objective: To compare the antioxidant and anti-genotoxic properties of Alpinia (A.) galanga, Curcuma (C.) amada, and C. caesia. Methods: Cytotoxicity of ethanolic extracts of A. galanga, C. amada, and C. caesia at selected doses was evaluated by trypan blue, MTT, and flow cytometry-based assays. Genotoxicity and anti-genotoxicity (against methyl methanesulfonate, 35 ?M and H2O2, 250 ?M) of these plants were studied by comet assay in human lymphocytes in vitro. Furthermore, DPPH, ABTS, FRAP, lipid peroxidation, and hydroxyl radical scavenging assays were performed to study the antioxidant potentials of the plants. Finally, anti-genotoxic potential of C. amada was validated in Swiss albino mice using comet assay. Phytochemical composition of C. amada was determined by GC/MS and HPLC. Results: The selected doses (2.5, 5, and 10 ?g/mL) of A. galanga, C. amada, and C. caesia were non-toxic by cytotoxicity tests. All three ethanolic extracts of plant rhizomes demonstrated antioxidant and anti-genotoxic properties against methyl methanesulfonate-and H2O2-induced oxidative stress in human peripheral blood lymphocytes in vitro. Multivariate analysis revealed that various antioxidant properties of these extracts in DPPH, ABTS, and FRAP assays were strongly correlated with their total phenolic constituents. C. amada extract conferred protection against cyclophosphamide-induced DNA damage in the bone marrow cells of mice and DNA damage was significantly inhibited by 2.5 mg/kg C. amada extract. Conclusions: C. amada is rich in potentially bioactive molecules and exhibits potent antioxidant activities. Its anti-genotoxicity against cyclophosphamide-induced oxidative stress is also confirmed in this study. 2021 Asian Pacific Journal of Tropical Biomedicine Produced by Wolters Kluwer-Medknow. All rights reserved. Creator An entity primarily responsible for making the resource Nag A.; Banerjee R.; Goswami P.; Bandyopadhyay M.; Mukherjee A. Source A related resource from which the described resource is derived Asian Pacific Journal of Tropical Biomedicine, Vol-11, No. 8, pp. 363-374. Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Date A point or period of time associated with an event in the lifecycle of the resource 2021-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.4103/2221-1691.319571" target="_blank" rel="noreferrer noopener">https://doi.org/10.4103/2221-1691.319571</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111058724&amp;doi=10.4103%2F2221-1691.319571&amp;partnerID=40&amp;md5=cee1b6416460dc470ab2ed17da15340e" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111058724&amp;doi=10.4103%2f2221-1691.319571&amp;partnerID=40&amp;md5=cee1b6416460dc470ab2ed17da15340e</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 22211691 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nag A., Department of Life Sciences, CHRIST (Deemed to Be University), Bangalore, India; Banerjee R., UGC-CAS, Department of Botany, University of Calcutta, Kolkata, India; Goswami P., UGC-CAS, Department of Botany, University of Calcutta, Kolkata, India; Bandyopadhyay M., UGC-CAS, Department of Botany, University of Calcutta, Kolkata, India; Mukherjee A., UGC-CAS, Department of Botany, University of Calcutta, Kolkata, India