Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mirabijalones S-W, rotenoids from rhizomes of white Mirabilis jalapa Linn. and their cell proliferative studies Subject The topic of the resource Cytotoxicity; Mirabijalones S-W; Mirabilis jalapa Linn; MTT; Nyctaginaceae; Rotenoids Description An account of the resource Five undescribed (2-6) rotenoid derivatives along with three known rotenoids (1, 7 and 8) were isolated from the rhizomes of white colored variety of Mirabilis jalapa Linn. The structures of these undescribed compounds were elucidated based on UV, IR, HR-MS (ESI), 1D and 2D NMR spectroscopic techniques. Selected compounds were evaluated for their cell viability and proliferation in two cancer cell lines namely, cervical (HeLa), breast (SKBR-3) and normal lung fibroblast (WI-38). Among them, the compounds Boeravinone C (1), Mirabijalone S (2), Mirabijalone T (3) and 4, 6, 11-trihydroxy-9-methoxy-10-methylchromeno [3, 4-b] chromen-12(6H)-one (8) showed moderate cytotoxicity against HeLa cells with IC50 values in the 8.40 ? 12.9 ?M range, and compound 8 exhibited cytotoxicity against SKBR-3 cells with IC50 value of 17.6 ?M. Molecular docking studies of isolated compounds were performed with three apoptosis proteins, 3H11, 2AR9 and 1X0X. These results revealed that the isolated compounds were found to interact with Caspase 8 and 9 along with the anti-apoptotic protein Survivin. Since these compounds exhibit cytotoxic effects against SKBR3 and HeLa cells, they are expected to show apoptosis and may be further utilized for wet lab apoptotic studies. 2021 Phytochemical Society of Europe Creator An entity primarily responsible for making the resource Sharathna P.; Alisha V.; Sasikumar P.; Ajesh V.; Ayisha F.; Shibi I.G.; Sivan V.V.; Kaustabh Kumar M.; Ravi S. L.; Radhakrishnan K.V. Source A related resource from which the described resource is derived Phytochemistry Letters, Vol-44, pp. 178-184. Publisher An entity responsible for making the resource available Elsevier Ltd Date A point or period of time associated with an event in the lifecycle of the resource 2021-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.phytol.2021.06.017" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.phytol.2021.06.017</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109004524&amp;doi=10.1016%2Fj.phytol.2021.06.017&amp;partnerID=40&amp;md5=8ef001731a67e0ae61cc850ffb87e4fa" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109004524&amp;doi=10.1016%2fj.phytol.2021.06.017&amp;partnerID=40&amp;md5=8ef001731a67e0ae61cc850ffb87e4fa</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 18743900; CODEN: PLHEB Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Sharathna P., Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram-19, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-002, India; Alisha V., Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram-19, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-002, India; Sasikumar P., Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram-19, India; Ajesh V., Department of Chemistry, CHRIST (Deemed to Be University), Hosur Road, Bengaluru, 560029, India; Ayisha F., Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram-19, India; Shibi I.G., Department of Chemistry, Sree Narayana College, Chempazhanthy, Thiruvananthapuram, India; Sivan V.V., M. S. Swaminathan Research Foundation-Community Agrobiodiversity Centre (MSSRF-CAbC), Puthurvayal, Wayanad, Kerala, India; Kaustabh Kumar M., Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram-19, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-002, India; Ravi S. L., Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram-19, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-002, India; Radhakrishnan K.V., Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram-19, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-002, India