Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Genetic and cytogenetic screening of autistic spectrum disorder: Genotype-phenotype profiles Subject The topic of the resource Autism; DSM IV-TR; FISH analysis; Karyotyping; NRXN1gene Description An account of the resource Autism, a pervasive developmental disorder typically characterized by repetitive behaviour, social skills deficit (or a deficit in social communication), speech and language impairments. Our prime focus is to analyze the clinical features and phenotypical behavioural changes using the diagnostic and statistical manual of mental disorders, fourth edition, text revision (DSM IV-TR), and locating the biomarkers associated with specific autistic characters using karyotyping and fluorescence in situ hybridization (FISH) techniques. The prevalence rate of the neurexin 1 (NRXN1) gene polymorphism was also assessed in the current study. The study group involved 196 samples with 98 autistics, and equal age-matched (2) controls based on their birth order and carrier. The participants include 35.2% males (n = 69) and 14.8% females (n = 29). The autistic and control participants were categorized based on their ages as group I (&lt;12 yrs) with n = 62; males n = 41 (20.9%); females n = 21 (10.7%) and group II (?12 yrs)-n = 36; males n = 28 (14.2%); females n = 08 (4.08%). Karyotyping was done for autism participants (n = 98) and the results showed that 90% of autistic participants were either the only child or the first child with a low perception and frequency in both the groups. Subsequently, we carried out the FISH assay on participants (n = 37) with higher DSM-IV TR score (?30). Only 30 FISH tests were negative for subtelomeric deletions with NRXN1 polymorphism genotypic frequency as 62.50%, 25% and 25% for A/A, A/G and G/G genotype respectively. Our study suggests the link between a haplotype with clinical signs of autism for the single nucleotide sequence (SNP rs9636391) and links autistic characters and gene among autistic children according to their birth order, age and gender in India. 2021 Elsevier B.V. Creator An entity primarily responsible for making the resource Meyyazhagan A.; Balasubramanian B.; Bhotla H.K.; Easwaran M.; Shanmugam S.; Alagamuthu K.K.; Arumugam V.A.; Keshavarao S.; Pappusamy M. Source A related resource from which the described resource is derived Meta Gene, Vol-29 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2021-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.mgene.2021.100924" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.mgene.2021.100924</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106518982&amp;doi=10.1016%2Fj.mgene.2021.100924&amp;partnerID=40&amp;md5=cd162d5c491763a5480e9f2950132b82" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106518982&amp;doi=10.1016%2fj.mgene.2021.100924&amp;partnerID=40&amp;md5=cd162d5c491763a5480e9f2950132b82</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 22145400 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Meyyazhagan A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India, Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, 641046, Tamil Nadu, India; Balasubramanian B., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, 641046, Tamil Nadu, India, Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Bhotla H.K., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, 641046, Tamil Nadu, India; Easwaran M., Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India; Shanmugam S., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, 641046, Tamil Nadu, India, Department of Animal Resource and Science, Dankook University, Cheonan, 31116, South Korea; Alagamuthu K.K., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, 641046, Tamil Nadu, India, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210023, China; Arumugam V.A., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India; Keshavarao S., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, 641046, Tamil Nadu, India; Pappusamy M., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India