Synthesis, Characterization and Studies of Hydrazine Based Polyfunctional Ligands and their Metal Chelates

Title

Synthesis, Characterization and Studies of Hydrazine Based Polyfunctional Ligands and their Metal Chelates

Creator

Juno Rose Attokkaran

Description

Eight new hydrazine-based zinc (II), copper (II) complexes were synthesized by reacting Zn (OAc)2.2H2O and Cu(CH3COO)2 with N'??(3,5-dibromo-2-hydroxy benzylidene) benzohydrazide (H2L1) and N'??(3,5-dibromo-2-hydroxy benzylidene) nicotinichydrazide (H2L2) respectively. The synthesized complexes were characterized by CHN analyses, IR, UV and 1H NMR. Based on these studies, square planar and octahedral geometries of the metal complexes were revealed. The synthesized metal complexes named [Zn(H2L1)2](OAc)2, [Zn(H2L1)Py](OAc)2, [ZnL2]2, [ZnL2Py], [CuL1]2, [CuL1Py], [CuL2]2 and [CuL2Py]. The formed metal complexes were investigated for DNA binding studies by fluorescence and UV spectroscopy using calf thymus DNA (CT-DNA) and DNA cleavage studies against pBR322 DNA. Both the ligands and their corresponding metal complexes showed the ability for binding to DNA through intercalation/ electrostatic binding.

Source

Chemistry

Date

2019