Size Tuning, Phase Stabilization, and Anticancer Efficacy of Amorphous Selenium Nanoparticles: Effect of Ion-Pair Interaction, ?OH Functionalization, and Reuse of RTILs as Host Matrix
- Title
- Size Tuning, Phase Stabilization, and Anticancer Efficacy of Amorphous Selenium Nanoparticles: Effect of Ion-Pair Interaction, ?OH Functionalization, and Reuse of RTILs as Host Matrix
- Creator
- Guleria A.; Baby C.M.; Tomy A.; Maurya D.K.; Neogy S.; Debnath A.K.; Adhikari S.
- Description
- Se nanoparticles (NPs) of predominantly amorphous phase (?-Se) have been prepared in room-temperature ionic liquids (RTILs). The effects of ion-pair combination and ?OH functionalization of RTILs on the size and phase stability of Se NPs were investigated. The RTILs used were 1-ethyl-3-methyl imidazolium boron tetrafluoride ([EMIM][BF4]), 1-(2-hydroxyethyl)-3-methyl imidazolium boron tetrafluoride ([EOHMIM][BF4]), and 1-ethyl-3-methyl imidazolium methane sulfonate ([EMIM][MS]). The size of Se NPs@[EOHMIM][BF4] was found to be the smallest (?32 nm), followed by Se NPs@[EMIM][BF4] (?57 nm) and Se NPs@[EMIM][MS] (?60 nm), respectively. Interestingly, the stability studies revealed minimal size variations for Se NPs@[EMIM][MS], followed by Se NPs@[EOHMIM][BF4] and Se NPs@[EMIM][BF4], respectively. The observed trends could be correlated with the strength of interionic interactions in the respective RTILs, as well as their packing order (density). Importantly, the RTILs played the role of a solvent, a stabilizer, and an in situ source of reducing species. Pulse radiolysis study revealed imidazolium-originated radical species-driven formation of Se NPs. Further, anticancer efficacy studies demonstrated the role of NP size, wherein Se NPs@[EOHMIM][BF4] exhibited the highest cancer cell killing, followed by Se NPs@[EMIM][BF4] and Se NPs@[EMIM][MS]. Another significant highlight of this work is the reuse of the spent RTILs for the synthesis of the next batch of Se NPs. 2021 American Chemical Society
- Source
- Journal of Physical Chemistry C, Vol-125, No. 25, pp. 13933-13945.
- Date
- 2021-01-01
- Publisher
- American Chemical Society
- Coverage
- Guleria A., Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Baby C.M., Christ University, Bengaluru, 560029, India; Tomy A., Christ University, Bengaluru, 560029, India; Maurya D.K., Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Neogy S., Materials Science Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Debnath A.K., Technical Physics Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Adhikari S., Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India
- Rights
- Restricted Access
- Relation
- ISSN: 19327447
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Guleria A.; Baby C.M.; Tomy A.; Maurya D.K.; Neogy S.; Debnath A.K.; Adhikari S., “Size Tuning, Phase Stabilization, and Anticancer Efficacy of Amorphous Selenium Nanoparticles: Effect of Ion-Pair Interaction, ?OH Functionalization, and Reuse of RTILs as Host Matrix,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/15763.