Transmission Jeopardy of Adenomatosis Polyposis Coli and Methylenetetrahydrofolate Reductase in Colorectal Cancer
description: Colorectal cancer (CRC) is one of the globally prevalent and virulent types of cancer with a distinct alteration in chromosomes. Often, any alterations in the adenomatosis polyposis coli (APC), a tumor suppressor gene, and methylenetetrahydrofolate reductase (MTHFR) gene are related to surmise colorectal cancer significantly. In this study, we have investigated chromosomal and gene variants to discern a new-fangled gene and its expression in the southern populations of India by primarily spotting the screened APC and MTHFR variants in CRC patients. An equal number of CRC patients and healthy control subjects ((Formula presented.)) were evaluated to observe a chromosomal alteration in the concerted and singular manner for APC and MTHFR genotypes using standard protocols. The increasing prognosis was observed in persons with higher alcoholism and smoking ((Formula presented.)) with frequent alterations in chromosomes 1, 5, 12, 13, 15, 17, 18, 21, and 22. The APC Asp 1822Val and MTHFR C677T genotypes provided significant results, while the variant alleles of this polymorphism were linked with an elevated risk of CRC. Chromosomal alterations can be the major cause in inducing carcinogenic outcomes in CRCs and can drive to extreme pathological states. 2021, SAGE Publications Ltd. All rights reserved.
creator: Mohd Y.; Kumar P.; Kuchi Bhotla H.; Meyyazhagan A.; Balasubramanian B.; Ramesh Kumar M.K.; Pappusamy M.; Alagamuthu K.K.; Orlacchio A.; Keshavarao S.; Sampathkumar P.; Arumugam V.A.
source: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, Vol-2021
publisher: SAGE Publications Ltd
date: 2021-01-01
rights: All Open Access; Green Open Access; Hybrid Gold Open Access
relation: ISSN: 14703203; PubMed ID: 34956401; CODEN: JRAAA
format: Online
language: English
type: Article
coverage: Mohd Y., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, School of Life Sciences, Bharathiar University, Tamil Nadu, 641046, India; Kumar P., Department of Zoology, Jammu University, Jammu and Kashmir, Jammu, 180006, India, Institution of Human Genetics, Jammu University, Jammu and Kashmir, Jammu, 180006, India; Kuchi Bhotla H., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Tamil Nadu, Coimbatore, 461046, India; Meyyazhagan A., Department of Life Sciences CHRIST (Deemed to be University), Bangalore, 560029, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Ramesh Kumar M.K., Department of General Surgery, Mahatma Gandhi Medical College and Research Institute, Pillaiyarkuppam, Pondicherry, 607403, India; Pappusamy M., Department of Life Sciences CHRIST (Deemed to be University), Bangalore, 560029, India; Alagamuthu K.K., Department of Biotechnology, Selvamm Arts and Science College (Autonomous), Tamil Nadu, Namakkal, 637003, India; Orlacchio A., Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello (CERC), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione Santa Lucia, Rome, Italy, Dipartimento di Medicina e Chirurgia, Universitdi Perugia, Perugia, Italy; Keshavarao S., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Tamil Nadu, Coimbatore, 461046, India; Sampathkumar P., Department of Chemistry and Biosciences, SASTRA Deemed to be University, Tamil Nadu, Kumbakonam, 612001, India; Arumugam V.A., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, School of Life Sciences, Bharathiar University, Tamil Nadu, 641046, India