Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Extending schizophrenia diagnostic model to predict schizotypy in first-degree relatives Description An account of the resource Recently, we developed a machine-learning algorithm EMPaSchiz that learns, from a training set of schizophrenia patients and healthy individuals, a model that predicts if a novel individual has schizophrenia, based on features extracted from his/her resting-state functional magnetic resonance imaging. In this study, we apply this learned model to first-degree relatives of schizophrenia patients, who were found to not have active psychosis or schizophrenia. We observe that the participants that this model classified as schizophrenia patients had significantly higher schizotypal personality scores than those who were not. Further, the EMPaSchiz probability score for schizophrenia status was significantly correlated with schizotypal personality score. This demonstrates the potential of machine-learned diagnostic models to predict state-independent vulnerability, even when symptoms do not meet the full criteria for clinical diagnosis. 2020, The Author(s). Creator An entity primarily responsible for making the resource Kalmady S.V.; Paul A.K.; Greiner R.; Agrawal R.; Amaresha A.C.; Shivakumar V.; Narayanaswamy J.C.; Greenshaw A.J.; Dursun S.M.; Venkatasubramanian G. Source A related resource from which the described resource is derived npj Schizophrenia, Vol-6, No. 1 Publisher An entity responsible for making the resource available Nature Research Date A point or period of time associated with an event in the lifecycle of the resource 2020-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1038/s41537-020-00119-y" target="_blank" rel="noreferrer noopener">https://doi.org/10.1038/s41537-020-00119-y</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097026109&amp;doi=10.1038%2Fs41537-020-00119-y&amp;partnerID=40&amp;md5=2adbe2c9d5fe1f75eb25c5e9a87f152c" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097026109&amp;doi=10.1038%2fs41537-020-00119-y&amp;partnerID=40&amp;md5=2adbe2c9d5fe1f75eb25c5e9a87f152c</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 2334265X Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Kalmady S.V., Alberta Machine Intelligence Institute, University of Alberta, Edmonton, AB, Canada, Canadian VIGOUR Centre, University of Alberta, Edmonton, AB, Canada; Paul A.K., Alberta Machine Intelligence Institute, University of Alberta, Edmonton, AB, Canada, Department of Computing Science, University of Alberta, Edmonton, AB, Canada; Greiner R., Alberta Machine Intelligence Institute, University of Alberta, Edmonton, AB, Canada, Department of Computing Science, University of Alberta, Edmonton, AB, Canada, Department of Psychiatry, University of Alberta, Edmonton, AB, Canada; Agrawal R., Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neuro Sciences, Bangalore, India; Amaresha A.C., Department of Sociology and Social Work, Christ- Deemed to be University Bangalore, Bangalore, India; Shivakumar V., Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India, Department of Integrative Medicine, National Institute of Mental Health and Neuro Sciences, Bangalore, India; Narayanaswamy J.C., Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neuro Sciences, Bangalore, India, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India; Greenshaw A.J., Department of Psychiatry, University of Alberta, Edmonton, AB, Canada; Dursun S.M., Department of Psychiatry, University of Alberta, Edmonton, AB, Canada; Venkatasubramanian G., Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neuro Sciences, Bangalore, India, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India