Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chloroform fraction of Chaetomorpha brachygona, a marine green alga from Indian Sundarbans inducing autophagy in cervical cancer cells in vitro Description An account of the resource Sundarbans Mangrove Ecosystem (SME) is a rich repository of bioactive natural compounds, with immense nutraceutical and therapeutic potential. Till date, the algal population of SME was not explored fully for their anticancer activities. Our aim is to explore the potential of these algal phytochemicals against the proliferation of cervical cancer cells (in vitro) and identify the mode of cell death induced in them. In the present work, the chloroform fraction of marine green alga, Chaetomorpha brachygona was used on SiHa cell line. The algal phytochemicals were identified by GCMS, LCMS and column chromatography and some of the identified compounds, known for significant anticancer activities, have shown strong Bcl-2 binding capacity, as analyzed through molecular docking study. The extract showed cytostatic and cytotoxic activity on SiHa cells. Absence of fragmented DNA, and presence of increased number of acidic vacuoles in the treated cells indicate nonapoptotic cell death. The mode of cell death was likely to be autophagic, as indicated by the enhanced expression of Beclin 1 and LC3BII (considered as autophagic markers) observed by Western blotting. The study indicates that, C. brachygona can successfully inhibit the proliferation of cervical cancer cells in vitro. 2020, The Author(s). Creator An entity primarily responsible for making the resource Majumder I.; Paul S.; Nag A.; Kundu R. Source A related resource from which the described resource is derived Scientific Reports, Vol-10, No. 1 Publisher An entity responsible for making the resource available Nature Research Date A point or period of time associated with an event in the lifecycle of the resource 2020-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1038/s41598-020-78592-9" target="_blank" rel="noreferrer noopener">https://doi.org/10.1038/s41598-020-78592-9</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097487911&amp;doi=10.1038%2Fs41598-020-78592-9&amp;partnerID=40&amp;md5=604924a7c2565596facb21292811ef05" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097487911&amp;doi=10.1038%2fs41598-020-78592-9&amp;partnerID=40&amp;md5=604924a7c2565596facb21292811ef05</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 20452322; PubMed ID: 33311531 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Majumder I., Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India; Paul S., School of Biotechnology, Presidency University, Canal Bank Rd, DG Block, Action Area 1D, New Town, 700156, West Bengal, India; Nag A., Department of Life Sciences, CHRIST (Deemed To Be University), Bangalore, 560029, India; Kundu R., Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India