ItemArticle

Biomarker study of the biological parameter and neurotransmitter levels in autistics

Title
Biomarker study of the biological parameter and neurotransmitter levels in autistics
Creator
Meyyazhagan A.; Balasubramanian B.; Easwaran M.; Alagamuthu K.K.; Shanmugam S.; Kuchi Bhotla H.; Pappusamy M.; Arumugam V.A.; Thangaraj A.; Kaul T.; Keshavarao S.; Cacabelos R.
Description
Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two groups of autistic subjects (group I < 12years; group II ? 12years). Antioxidants show a variation of 10% increase in controls compared to autistic age < 12years. The concentration of pyruvate kinase and hexokinase is elevated in controls approximately 60% and 45%, respectively, with the significance of 95 and 99%. Autistic subjects showed marked variation in levels of neurotransmitters, oxidative stress and its related ions. Cumulative assessment of parameters related to biochemical markers and neurotransmitters paves the way for autism-based research, although these observations draw interest in an integrated approach for autism. 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Source
Molecular and Cellular Biochemistry, Vol-474, No. 45689, pp. 277-284.
Date
2020-01-01
Publisher
Springer
Subject
Antioxidant proteins; Autism; Biochemical; Neurotransmitters; Oxidative stress
Coverage
Meyyazhagan A., EuroEspes Biomedical Research Centre, International Center of Neurosciences and Genomic Medicine, Bergondo, Corunna, 15165, Spain, Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India, Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, Karnataka, India; Balasubramanian B., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India, Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Easwaran M., Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India; Alagamuthu K.K., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India, Jiagsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210023, China; Shanmugam S., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India, Department of Animal Resource and Science, Dankook University, Cheonan, 31116, South Korea; Kuchi Bhotla H., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India; Pappusamy M., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, Karnataka, India; Arumugam V.A., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India; Thangaraj A., Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India; Kaul T., Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India; Keshavarao S., Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India; Cacabelos R., EuroEspes Biomedical Research Centre, International Center of Neurosciences and Genomic Medicine, Bergondo, Corunna, 15165, Spain
Rights
Restricted Access
Relation
ISSN: 3008177; PubMed ID: 32740790; CODEN: MCBIB
Format
Online
Language
English
Type
Article

Collection

Articles

Citation

Meyyazhagan A.; Balasubramanian B.; Easwaran M.; Alagamuthu K.K.; Shanmugam S.; Kuchi Bhotla H.; Pappusamy M.; Arumugam V.A.; Thangaraj A.; Kaul T.; Keshavarao S.; Cacabelos R., “Biomarker study of the biological parameter and neurotransmitter levels in autistics,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/16174.

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