Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Piperine, an alkaloid of black pepper seeds can effectively inhibit the antiviral enzymes of Dengue and Ebola viruses, an in silico molecular docking study Subject The topic of the resource Black pepper; Dengue; Ebola; In silico docking; Piperine Description An account of the resource Ebola and Dengue are the critical diseases caused by RNA viruses, especially in the tropical parts of the globe, including Asia and Africa, and no prominent therapeutic options are available so far. Here, an effort was made to evaluate the efficacy of black pepper (Piper nigrum L.) alkaloid Piperine as a potential drug through computational docking simulation. Eight structurally essential proteins of Dengue and Ebola virus were selected as in silico docking targets for Piperine. Absorption, Distribution, Metabolism, and Excretion profile showed that Piperine was safe and possessed significant drug-like properties. Molecular dynamic simulation and binding free energy calculation showed that Piperine could inhibit Methyltransferase (PDB id 1L9K) of Dengue and VP35 Interferon Inhibitory Domain (PDB id 3FKE) of Ebola virus in comparison with the commercial antiviral Ribavirin. Furthermore, statistical analysis based on multivariate and clustering approaches revealed that Piperine had more affinity towards viral proteins than that of Ribavirin. 2020, Indian Virological Society. Creator An entity primarily responsible for making the resource Nag A.; Chowdhury R.R. Source A related resource from which the described resource is derived VirusDisease, Vol-31, No. 3, pp. 308-315. Publisher An entity responsible for making the resource available Springer Date A point or period of time associated with an event in the lifecycle of the resource 2020-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s13337-020-00619-6" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s13337-020-00619-6</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089017098&amp;doi=10.1007%2Fs13337-020-00619-6&amp;partnerID=40&amp;md5=1df0320c55b92df3b86161aefbdcee0a" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089017098&amp;doi=10.1007%2fs13337-020-00619-6&amp;partnerID=40&amp;md5=1df0320c55b92df3b86161aefbdcee0a</a> Rights Information about rights held in and over the resource All Open Access; Green Open Access Relation A related resource ISSN: 23473584 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nag A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Chowdhury R.R., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India