Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Synthesis, spectral and DNA/Protein binding evaluation of novel Cu(II) chelates of an NNO donor tridentate aroylhydrazone: Halogen bonding directed close packing Subject The topic of the resource Aroylhydrazone; Benzhydrazide; DNA/Protein binding; Gel electrophoresis; Halogen bonding; Molecular docking Description An account of the resource An NNO donor aroylhydrazone monohydrate, HFPBH2O (3-fluoropyridine-2-carbaldehyde benzoylhydrazone monohydrate) was synthesized from 3-fluoropyridine-2-carbaldehyde and benzhydrazide and physicochemically characterised. The coordination behaviour of the aroylhydrazone with the metal ion is investigated through various physicochemical techniques and it is concluded that it binds to the metal ion predominantly in the enolate resonance form, while few complexes exhibit keto form of the ligand. The structure of [Cu(FPB)(OAc)(H2O)]H2O (4a) established by single-crystal X-ray diffraction method unveiled that the metal ion has a distorted square-pyramidal geometry in this complex. The coordination sites of Cu(II) ion are occupied by azomethine N, pyridyl N and iminolate O from a monodeprotonated hydrazone moiety and the remaining two positions are occupied by two oxygen atoms, one each from acetate ion and the water molecule. Potential applications of the complexes were studied by subjecting them to DNA/protein (BSA) binding studies using electronic and fluorescence spectroscopy. The complexes were found to bind with DNA/protein (BSA) with binding constants in the order of 104 M?1 to 105 M?1. The intercalative mode of binding of the complexes with DNA was proved using spectral studies and molecular docking. Furthermore, the complex [Cu(FPB)(N3)(H2O)2] (5) was found to cleave the DNA from form I to form II during gel electrophoresis studies. 2020 Elsevier B.V. Creator An entity primarily responsible for making the resource Nair Y.S.; Venkataraman S.K.; Joy F.; Krishna P.M.; Agarwal A.K.; Vinod T.P.; Madathil P.K.; Kurup M.R.P. Source A related resource from which the described resource is derived Journal of Molecular Structure, Vol-1217 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2020-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.molstruc.2020.128453" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.molstruc.2020.128453</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085237766&amp;doi=10.1016%2Fj.molstruc.2020.128453&amp;partnerID=40&amp;md5=4781e1305b531d5d38cfdc17f22223d5" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085237766&amp;doi=10.1016%2fj.molstruc.2020.128453&amp;partnerID=40&amp;md5=4781e1305b531d5d38cfdc17f22223d5</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 222860; CODEN: JMOSB Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nair Y.S., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Venkataraman S.K., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Joy F., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Krishna P.M., Department of Chemistry, M. S. Ramaiah Institute of Technology, Bangalore, 560 054, India; Agarwal A.K., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Vinod T.P., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Madathil P.K., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Kurup M.R.P., Department of Chemistry, School of Physical Sciences, Central University of Kerala, Tejaswini Hills, Periye, Kasaragod, 671 320, India