Antibacterial performance of GOAg nanocomposite prepared via ecologically safe protocols
- Title
- Antibacterial performance of GOAg nanocomposite prepared via ecologically safe protocols
- Creator
- Thomas R.; Unnikrishnan J.; Nair A.V.; Daniel E.C.; Balachandran M.
- Description
- Control and extinction of the rising problem of antimicrobial resistance makes a multidisciplinary approach for the advancement of novel disinfectant agents imperative. Although graphene-based nanomaterials display high bacterial toxicity, their cytotoxicity to mammalian cells is found to be very low. Herein, a simple green approach for the synthesis of graphene oxidesilver composite using Syzgium cumini (Indian black plum) fruit extract was reported. Physicochemical properties and antibacterial activities of the composite were subsequently studied comparing with silver nanoparticles and pure graphene oxide. We demonstrate the influence of precursor materials in dictating the antibacterial properties of nanosystems. The antibacterial study conducted on selected gram-negative and gram-positive bacteria reveals that composite is more effective against gram-negative bacteria. The microbicidal activity of composite against bacteria Pseudomonas aeruginosa and E. coli, was higher than the control drug cephalexin (CE control). Test compounds against L929 cell lines by MTT assay reveal the low cytotoxicity of samples. From the statistical analysis, it is inferred that the cell viability is dependent on the concentration. Fruit extract-based graphenesilver composite could be an excellent environment-friendly replacement for harsh disinfectants. 2020, King Abdulaziz City for Science and Technology.
- Source
- Applied Nanoscience (Switzerland), Vol-10, No. 11, pp. 4207-4219.
- Date
- 2020-01-01
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Antibacterial activity; ESKAPE pathogens; Graphenesilver composite
- Coverage
- Thomas R., Department of Physics and Electronics, CHRIST (Deemed to be University), Bengaluru, 560029, Karnataka, India; Unnikrishnan J., Department of Statistics, Kristu Jayanti College (Autonomous), Bengaluru, 560077, Karnataka, India; Nair A.V., Department of Physics and Electronics, CHRIST (Deemed to be University), Bengaluru, 560029, Karnataka, India; Daniel E.C., Department of Life Sciences, Kristu Jayanti College (Autonomous), Bengaluru, 560077, Karnataka, India; Balachandran M., Department of Physics and Electronics, CHRIST (Deemed to be University), Bengaluru, 560029, Karnataka, India
- Rights
- Restricted Access
- Relation
- ISSN: 21905509
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Thomas R.; Unnikrishnan J.; Nair A.V.; Daniel E.C.; Balachandran M., “Antibacterial performance of GOAg nanocomposite prepared via ecologically safe protocols,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/16232.