Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Acetylcholine esterase inhibition activity of leaf extract of Saraca asoca using zebrafish as model organism Subject The topic of the resource Acetylcholine esterase (AChE); Alzheimers disease; Molecular docking; Saraca asoca; Zebrafish Description An account of the resource Alzheimers disease, also called as Senile Dementia, is a progressive neurogenerative disease that slowly destroys important mental functions like memory, reasoning and thinking. A plethora of factors including genetics, lifestyle, environment, age etc. play a part in determining its incidence. One of the commonly used techniques to slow down the progression of Alzheimers is to reduce the functioning of Acetylcholinesterase (AChE) enzyme which breaks down the neurotransmitter acetylcholine. Plants have been found to be natural sources of AChE inhibitors. Hence the present investigation was an attempt to screen Ashoka plant (Saraca asoca) for such inhibitors. Zebrafish (Danio rerio) was used as a model organism due to its genetic similarities with humans. Both in vivo and in vitro analyses using zebrafish indicated inhibitory action of the leaf extract on AChE. Gas Chromatography- Mass spectrometry (GCMS) analysis of the methanolic leaf extract and further docking studies of prominent phytochemicals revealed the AChE inhibitory potential of molecules like Stigmasterol, ?-sitosterol, Vitamin E etc. Hence these molecules can be thought of as targets in the therapy of Alzheimers disease. 2020 World Research Association. All rights reserved. Creator An entity primarily responsible for making the resource Rijo R.; Tilling B.R.; Mehul V.A.; Sumit P.; Suma S. Source A related resource from which the described resource is derived Research Journal of Chemistry and Environment, Vol-24, No. 6, pp. 88-94. Publisher An entity responsible for making the resource available World Research Association Date A point or period of time associated with an event in the lifecycle of the resource 2020-01-01 Identifier An unambiguous reference to the resource within a given context <a href="" target="_blank" rel="noreferrer noopener"></a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087353100&amp;partnerID=40&amp;md5=32c19a03e25fb091002d66cb96bdfcd9" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087353100&amp;partnerID=40&amp;md5=32c19a03e25fb091002d66cb96bdfcd9</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 9720626 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Rijo R., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Tilling B.R., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Mehul V.A., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Sumit P., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Suma S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India