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              <text>Base mediated spirocyclization of quinazoline: One-step synthesis of spiro-isoindolinone dihydroquinazolinones</text>
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              <text>A novel approach for the spiro-isoindolinone dihydroquinazolinones has been demonstrated from 2-aminobenzamide and 2-cyanomethyl benzoate in the presence of KHMDS as a base to get moderate yields. The reaction has been screened in various bases followed by solvents and a gram scale reaction has also been executed under the given conditions. Based on the controlled experiments a plausible reaction mechanism has been proposed. Further the substrate scope of this reaction has also been studied. This journal is  The Royal Society of Chemistry.</text>
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              <text>Venkateshwarlu R.; Murthy V.N.; Tadiparthi K.; Nikumbh S.P.; Jinkala R.; Siddaiah V.; Madhu Babu M.V.; Rama Mohan H.; Raghunadh A.</text>
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              <text>RSC Advances, Vol-10, No. 16, pp. 9486-9491.</text>
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              <text>&lt;a href="https://doi.org/10.1039/c9ra09567e" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.1039/c9ra09567e&lt;/a&gt;
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              <text>All Open Access; Gold Open Access; Green Open Access</text>
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              <text>ISSN: 20462069; CODEN: RSCAC</text>
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              <text>Venkateshwarlu R., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India, Department of Organic Chemistry and FDW, Andhra University, Visakhapatnam, 530045, India; Murthy V.N., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Tadiparthi K., Department of Chemistry, CHRIST (Deemed to Be University) Hosur Road, Bengaluru, 560029, India; Nikumbh S.P., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Jinkala R., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Siddaiah V., Department of Organic Chemistry and FDW, Andhra University, Visakhapatnam, 530045, India; Madhu Babu M.V., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Rama Mohan H., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Raghunadh A., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India</text>
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