Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol
- Title
- Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol
- Creator
- Sharma E.; Jacob P.; Murthy P.; Jain S.; Varghese M.; Jayarajan D.; Kumar K.; Benegal V.; Vaidya N.; Zhang Y.; Desrivieres S.; Schumann G.; Iyengar U.; Holla B.; Purushottam M.; Chakrabarti A.; Fernandes G.S.; Heron J.; Hickman M.; Kartik K.; Kalyanram K.; Rangaswamy M.; Bharath R.D.; Barker G.; Orfanos D.P.; Ahuja C.; Thennarasu K.; Basu D.; Subodh B.N.; Kuriyan R.; Kurpad S.S.; Kumaran K.; Krishnaveni G.; Krishna M.; Singh R.L.; Singh L.R.; Toledano M.
- Description
- Background: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns. 2019 The Author(s).
- Source
- BMC Psychiatry, Vol-20, No. 1
- Date
- 2020-01-01
- Publisher
- BioMed Central Ltd.
- Subject
- Cohort; Environmental exposures; Externalizing disorders; Longitudinal study; Study protocol; Vulnerabilities
- Coverage
- Sharma E., Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Jacob P., Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Murthy P., Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Jain S., Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Varghese M., Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Jayarajan D., Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Kumar K., Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Benegal V., Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Vaidya N., Centre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry and Neuroscience, MRC SGDP Centre, King's College London, London, United Kingdom; Zhang Y., Centre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry and Neuroscience, MRC SGDP Centre, King's College London, London, United Kingdom; Desrivieres S., Centre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry and Neuroscience, MRC SGDP Centre, King's College London, London, United Kingdom; Schumann G., Centre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry and Neuroscience, MRC SGDP Centre, King's College London, London, United Kingdom; Iyengar U., Department of Child and Adolescent Psychiatry, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, United Kingdom; Holla B., Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Purushottam M., Molecular Genetics Laboratory, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Chakrabarti A., Regional Occupational Health Centre (ROHC), Eastern, ICMR-National Institute of Occupational Health (NIOH), Kolkata, West Bengal, India; Fernandes G.S., Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Heron J., Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Hickman M., Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Kartik K., Rishi Valley Rural Health Centre, Madanapalle, Chittoor, Andhra Pradesh, India; Kalyanram K., Rishi Valley Rural Health Centre, Madanapalle, Chittoor, Andhra Pradesh, India; Rangaswamy M., Department of Psychology, Christ University, Bangalore, Karnataka, India; Bharath R.D., Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Barker G., Department of Neuroimaging, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, United Kingdom; Orfanos D.P., NeuroSpin, CEA, UniversitParis-Saclay, Paris, France; Ahuja C., Department of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; Thennarasu K., Department of Biostatistics, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India; Basu D., Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; Subodh B.N., Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; Kuriyan R., Division of Nutrition, St John's Research Institute, Bengaluru, India; Kurpad S.S., Department of Psychiatry, St. John's Medical College and Hospital, Bengaluru, India; Kumaran K., MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom; Krishnaveni G., Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India; Krishna M., Foundation for Research and Advocacy in Mental Health, Mysore, India; Singh R.L., Department of Psychiatry, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India; Singh L.R., Department of Clinical Psychology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India; Toledano M., Faculty of Medicine, School of Public Health, Imperial College, London, United Kingdom
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 1471244X; PubMed ID: 31898525; CODEN: BPMSC
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Sharma E.; Jacob P.; Murthy P.; Jain S.; Varghese M.; Jayarajan D.; Kumar K.; Benegal V.; Vaidya N.; Zhang Y.; Desrivieres S.; Schumann G.; Iyengar U.; Holla B.; Purushottam M.; Chakrabarti A.; Fernandes G.S.; Heron J.; Hickman M.; Kartik K.; Kalyanram K.; Rangaswamy M.; Bharath R.D.; Barker G.; Orfanos D.P.; Ahuja C.; Thennarasu K.; Basu D.; Subodh B.N.; Kuriyan R.; Kurpad S.S.; Kumaran K.; Krishnaveni G.; Krishna M.; Singh R.L.; Singh L.R.; Toledano M., “Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 26, 2025, https://archives.christuniversity.in/items/show/16362.