Beta carotene inhibiting HIV-1 reverse transcriptase, an in silico approach

Title

Beta carotene inhibiting HIV-1 reverse transcriptase, an in silico approach

Creator

Nag A.; Reema D.

Description

Due to the outspread of various emerging diseases, research on the discovery of new drugs is being carried out extensively. Several phytochemicals with medicinal importance are now being used for this purpose due to its effectiveness and safety in comparison to the conventional synthetic ones. Computational docking is further being used for the fast and cost-effective screening. Reverse transcriptase is a key enzyme involved in the conversion of viral RNA sequence into complementary DNA (cDNA) sequence leading to various retroviral diseases like HIV/AIDS. Patchdock docking server was used in this study to perform in silico enzyme-inhibitor binding experiment between twenty phytocompounds and HIV-1 reverse transcriptase enzyme. Beta-carotene was found to have strongest binding potential in comparison to other phytochemicals. The results suggested that this compound can be used as therapeutics in the future as naturally occurring HIV-1 reverse transcriptase inhibitor. 2020 World Research Association. All rights reserved.

Source

Research Journal of Biotechnology, Vol-15, No. 1, pp. 69-73.

Date

2020-01-01

Publisher

World Research Association

Subject

Beta-carotene; Docking; In silico; Phytochemicals; Reverse transcriptase

Coverage

Nag A., CHRIST (Deemed to be University), Bangalore, 560029, India; Reema D., CHRIST (Deemed to be University), Bangalore, 560029, India

Rights

Restricted Access

Relation

ISSN: 9736263

Format

Online

Language

English

Type

Article

Identifier

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078586671&partnerID=40&md5=cbdeba6200de969a20dc3c0260c409c6