Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Assessment of microsatellite instability for screening bladder cancer in high-risk population Subject The topic of the resource Bladder cancer; microsatellite instability; microsatellite markers Description An account of the resource Aims: This study aims to determine the diagnostic efficacy of microsatellite markers for screening bladder cancer in population at high risk. Materials and Methods: A population of 200 people was screened for bladder cancer using a set of microsatellite markers. Urine samples were obtained from four different types of population groups - Group 1 (healthy population group), Group 2 (current smokers with a smoking history of more than 10 years), Group 3 (bladder cancer group), and Group 4 (bladder cancer group who were former smokers with a history of more than 10 years). Polymerase chain reaction (PCR) was performed to amplify microsatellite sequences at D9S63, D9S156, and D9S283. PCR products were separated on 1.8% agarose gel and were scanned using ultraviolet transilluminator. Results: In Group 2 (high-risk population group, mainly current smokers with a history of more than 10 years), microsatellite alterations were found in 36 out of 50 people. We observed microsatellite alterations in 38 out of 50 people in Group 3 (bladder cancer group) and in 39 out of 50 people in Group 4 (bladder cancer group, mainly former smokers with a history of more than 10 years). The sensitivity of this test in Group 2, Group 3, and Group 4 was found to be 72%, 76% and 78%, respectively. The specificity of this test in each group was found to be 90%. Conclusion: Using these set of microsatellite markers, medium sensitivity and high specificity were reported for this test. The current findings suggest that a set of microsatellite markers (D9S63, D9S156, and D9S283) can be used to detect bladder cancer in high-risk population. 2018 Medknow Publications. All Rights Reserved. Creator An entity primarily responsible for making the resource Wadhwa N.; Mathew B.; Tandon S.; Biju V.; Tiwari A. Source A related resource from which the described resource is derived Journal of Cancer Research and Therapeutics, Vol-14, No. 5, pp. 916-920. Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Date A point or period of time associated with an event in the lifecycle of the resource 2018-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.4103/jcrt.JCRT_346_13" target="_blank" rel="noreferrer noopener">https://doi.org/10.4103/jcrt.JCRT_346_13</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053342351&amp;doi=10.4103%2Fjcrt.JCRT_346_13&amp;partnerID=40&amp;md5=f8325244f6b39060b028de8f3dc31e8c" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053342351&amp;doi=10.4103%2fjcrt.JCRT_346_13&amp;partnerID=40&amp;md5=f8325244f6b39060b028de8f3dc31e8c</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 9731482; PubMed ID: 30197325 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Wadhwa N., School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, State Technological University of Madhya Pradesh, Airport Bypass Road, Bhopal, Madhya Pradesh, 462 033, India; Mathew B., School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, State Technological University of Madhya Pradesh, Airport Bypass Road, Bhopal, Madhya Pradesh, 462 033, India; Tandon S., Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal, Madhya Pradesh, India; Biju V., Department of Computer Science and Engineering, Christ University, Kanmaike, Kumbalagodu, Bengaluru, Karnataka, India; Tiwari A., School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, State Technological University of Madhya Pradesh, Airport Bypass Road, Bhopal, Madhya Pradesh, 462 033, India