Citric-Acid-Catalyzed Green and Sustainable Synthesis of Novel Functionalized Pyrano[2, 3-e]pyrimidin- and Pyrano[2, 3-d]pyrazol-amines in Water via One-Pot Multicomponent Approaches
- Title
- Citric-Acid-Catalyzed Green and Sustainable Synthesis of Novel Functionalized Pyrano[2, 3-e]pyrimidin- and Pyrano[2, 3-d]pyrazol-amines in Water via One-Pot Multicomponent Approaches
- Creator
- Govindaraju S.; Tabassum S.; Pasha M.A.
- Description
- An efficient entry into the preparation of elusive, novel pyrano[2, 3-e]pyrimidin-amines and pyrano[2, 3-d]pyrazol-amines has been accomplished using citric acid as a green catalyst in aqueous medium at 25 C. The strategy successively tolerates a variety of functional groups and interestingly, it is eco-compatible, environment-friendly, propitious and the products are obtained in excellent yields without chromatographic purification. The current methodology unfolds the benefits of citric acid as an effective, expeditious, economical, green catalyst and thus adheres to the principles of green chemistry. Ecstatically, the reaction was scaled to the gram level ascertaining the wide applicability of the protocol in academia and industry. The green metrics (E-factor: 0.0497, Mass intensity: 1.1022, PMI: 1.0497 and Emw: 0.0497) for the reaction was also envisaged and the pathway was found to acquaint excellent green chemistry metrics. 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- Source
- ChemistrySelect, Vol-3, No. 13, pp. 3832-3838.
- Date
- 2018-01-01
- Publisher
- Wiley-Blackwell
- Subject
- 1H,4H-pyrano[2, 3-d]pyrazol-amines; citric acid; green chemistry metrics; one-pot multicomponent synthesis; pyrano[2, 3-e]pyrimidin-amines
- Coverage
- Govindaraju S., Department of Science and humanities, Christ (Deemed to be University), Faculty of Engineering, Kumbalagodu, Mysore Road, Bengaluru, 560074, India; Tabassum S., Department of Studies in Chemistry, Central College Campus, Bangalore University, Palace Road, Bengaluru, 560001, India; Pasha M.A., Department of Studies in Chemistry, Central College Campus, Bangalore University, Palace Road, Bengaluru, 560001, India
- Rights
- Restricted Access
- Relation
- ISSN: 23656549
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Govindaraju S.; Tabassum S.; Pasha M.A., “Citric-Acid-Catalyzed Green and Sustainable Synthesis of Novel Functionalized Pyrano[2, 3-e]pyrimidin- and Pyrano[2, 3-d]pyrazol-amines in Water via One-Pot Multicomponent Approaches,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/16967.