Efficient discrimination by MIRU-VNTRs of Mycobacterium tuberculosis clinical isolates belonging to the predominant SIT11/EAI3-IND ancestral genotypic lineage in Kerala, India
- Title
- Efficient discrimination by MIRU-VNTRs of Mycobacterium tuberculosis clinical isolates belonging to the predominant SIT11/EAI3-IND ancestral genotypic lineage in Kerala, India
- Creator
- Joseph B.V.; Soman S.; Hill V.; Kumar R.A.; Rastogi N.; Mundayoor S.
- Description
- The present study evaluated the ability of MIRU-VNTRs to discriminate Mycobacterium tuberculosis (MTB) clinical isolates belonging to the SIT11/EAI3-IND ancestral genotypic lineage, which is highly prevalent in Kerala, India. Starting from 168 MTB clinical isolates, spoligotyping (discriminatory index of 0.9113) differentiated the strains into 68 distinct patterns, the biggest cluster being SIT11/48 SIT11 ( n= 48). The present study shows that 12-loci MIRUs and 3 ETRs allowed an efficient discrimination of these isolates (discriminatory indexes of 0.7819 and 0.5523, respectively). 2013 Asian-African Society for Mycobacteriology.
- Source
- International Journal of Mycobacteriology, Vol-2, No. 4, pp. 244-247.
- Date
- 2013-01-01
- Subject
- India; IS6110-RFLP; Kerala; MIRU-VNTR; Mycobacterium tuberculosis; Spoligotyping
- Coverage
- Joseph B.V., Department of Biotechnology, Christ University, Bangalore 560 029, Karnataka, Hosur Road, India; Soman S., Mycobacteria Research Group, Department of Molecular Microbiology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695 014, Kerala, Thycaud Post, India; Hill V., WHO Supranational TB Reference Laboratory, TB and Mycobacteria Unit, Institut Pasteur de la Guadeloupe, Abymes, France; Kumar R.A., Mycobacteria Research Group, Department of Molecular Microbiology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695 014, Kerala, Thycaud Post, India; Rastogi N., WHO Supranational TB Reference Laboratory, TB and Mycobacteria Unit, Institut Pasteur de la Guadeloupe, Abymes, France; Mundayoor S., Mycobacteria Research Group, Department of Molecular Microbiology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695 014, Kerala, Thycaud Post, India
- Rights
- All Open Access; Gold Open Access
- Relation
- ISSN: 22125531
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Joseph B.V.; Soman S.; Hill V.; Kumar R.A.; Rastogi N.; Mundayoor S., “Efficient discrimination by MIRU-VNTRs of Mycobacterium tuberculosis clinical isolates belonging to the predominant SIT11/EAI3-IND ancestral genotypic lineage in Kerala, India,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/17261.